Sameer Agnihotri

Department of Medical Biophysics
University of Toronto, Canada

Fields of interest

Neural plasticity, memory and mechanisms of neural disease such as Parkinson’s, Alzheimer’s and initiation of primary brain tumours.


Recent publications

Agnihotri S, Gajadhar AS, Ternamian C, Gorlia T, Diefes KL, Mischel PS, Kelly J, McGown G, Thorncroft M, Carlson BL, Sarkaria JN, Margison GP, Aldape K, Hawkins C, Hegi M, Guha A.:
Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.
J Clin Invest., 2012, 122(1):253-66

Wolf A, Agnihotri S, Munoz D, Guha A.:
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Neurobiol Dis., 2011, 44(1):84-91

Agnihotri S, Wolf A, Munoz DM, Smith CJ, Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, McGlade CJ, Stanford WL, Aldape K, Mischel PS, Hawkins C, Guha A.:
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.
J Exp Med., 2011, 208(4):689-702

Wolf A, Agnihotri S, Guha A.:
Targeting metabolic remodeling in glioblastoma multiforme.
Oncotarget., 2010, 1(7):552-62

Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A.:
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
J Exp Med., 2011, 208(2):313-26

Restrepo A, Smith CA, Agnihotri S, Shekarforoush M, Kongkham PN, Seol HJ, Northcott P, Rutka JT.:
Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas.
Neuro Oncol., 2011, 13(1):42-50