Joseph Antony, PhD

Research Scientist
KGK Synergize Inc.
E-mail: joseph.antony@utoronto.ca
Page: http://network.nature.com/profile/U5333EC81

Fields of interest

Neurodevelopmental and neuropathological disorders, genes modulating stem cell behavior in the brain  with the goal of manipulating stem cell mediated brain repair and regeneration.

Recent publications

1: Russell JN, Marsh AK, Willer DO, Ambagala AP, Dzamba M, Chan JK, Pilon R,
Fournier J, Brudno M, Antony JM, Sandstrom P, Evans BJ, MacDonald KS. A novel
strain of cynomolgus macaque cytomegalovirus: implications for host-virus
co-evolution. BMC Genomics. 2016 Apr 5;17:277. doi: 10.1186/s12864-016-2588-3.
PubMed PMID: 27044312; PubMed Central PMCID: PMC4820910.

2: Marsh AK, Ambagala AP, Perciani CT, Russell JN, Chan JK, Janes M, Antony JM,
Pilon R, Sandstrom P, Willer DO, MacDonald KS. Examining the species-specificity
of rhesus macaque cytomegalovirus (RhCMV) in cynomolgus macaques. PLoS One. 2015
Mar 30;10(3):e0121339. doi: 10.1371/journal.pone.0121339. Erratum in: PLoS One.
2015;10(5):e0128733. PubMed PMID: 25822981; PubMed Central PMCID: PMC4378995.

3: Antony JM, MacDonald KS. A critical analysis of the cynomolgus macaque, Macaca
fascicularis, as a model to test HIV-1/SIV vaccine efficacy. Vaccine. 2015 Jun
17;33(27):3073-83. doi: 10.1016/j.vaccine.2014.12.004. Review. PubMed PMID:
25510387.

4: Bhat RK, Rudnick W, Antony JM, Maingat F, Ellestad KK, Wheatley BM, Tönjes RR,
Power C. Human endogenous retrovirus-K(II) envelope induction protects neurons
during HIV/AIDS. PLoS One. 2014 Jul 2;9(7):e97984. doi:
10.1371/journal.pone.0097984. PubMed PMID: 24988390; PubMed Central PMCID:
PMC4079299.

5: Antony JM, Paquin A, Nutt SL, Kaplan DR, Miller FD. Endogenous microglia
regulate development of embryonic cortical precursor cells. J Neurosci Res. 2011
Mar;89(3):286-98. doi: 10.1002/jnr.22533. PubMed PMID: 21259316.

6: Power C, Antony JM, Ellestad KK, Deslauriers A, Bhat R, Noorbakhsh F. The
human microbiome in multiple sclerosis: pathogenic or protective constituents?
Can J Neurol Sci. 2010 Sep;37 Suppl 2:S24-33. Review. PubMed PMID: 21246932.

7: Antony JM. Grooming and growing with microglia. Sci Signal. 2010 Nov
9;3(147):jc8. doi: 10.1126/scisignal.3147jc8. PubMed PMID: 21062990.

8: Antony JM, Deslauriers AM, Bhat RK, Ellestad KK, Power C. Human endogenous
retroviruses and multiple sclerosis: innocent bystanders or disease determinants?
Biochim Biophys Acta. 2011 Feb;1812(2):162-76. doi: 10.1016/j.bbadis.2010.07.016.
Review. PubMed PMID: 20696240.

9: Afkhami-Goli A, Liu SH, Zhu Y, Antony JM, Arab H, Power C. Dual lentivirus
infection potentiates neuroinflammation and neurodegeneration: viral copassage
enhances neurovirulence. J Neurovirol. 2009 Apr;15(2):139-52. doi:
10.1080/13550280802534763. PubMed PMID: 19115133.

10: Antony JM, Zhu Y, Izad M, Warren KG, Vodjgani M, Mallet F, Power C.
Comparative expression of human endogenous retrovirus-W genes in multiple
sclerosis. AIDS Res Hum Retroviruses. 2007 Oct;23(10):1251-6. PubMed PMID:
17961112.

11: Antony JM, Ellestad KK, Hammond R, Imaizumi K, Mallet F, Warren KG, Power C.
The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates
neuroinflammation and its receptor expression in multiple sclerosis: a role for
endoplasmic reticulum chaperones in astrocytes. J Immunol. 2007 Jul
15;179(2):1210-24. PubMed PMID: 17617614.

12: Zhu Y, Antony JM, Martinez JA, Glerum DM, Brussee V, Hoke A, Zochodne D,
Power C. Didanosine causes sensory neuropathy in an HIV/AIDS animal model:
impaired mitochondrial and neurotrophic factor gene expression. Brain. 2007
Aug;130(Pt 8):2011-23. PubMed PMID: 17616550.

13: Antony JM, Izad M, Bar-Or A, Warren KG, Vodjgani M, Mallet F, Power C.
Quantitative analysis of human endogenous retrovirus-W env in neuroinflammatory
diseases. AIDS Res Hum Retroviruses. 2006 Dec;22(12):1253-9. PubMed PMID:
17209768.

14: Heit B, Jones G, Knight D, Antony JM, Gill MJ, Brown C, Power C, Kubes P. HIV
and other lentiviral infections cause defects in neutrophil chemotaxis,
recruitment, and cell structure: immunorestorative effects of
granulocyte-macrophage colony-stimulating factor. J Immunol. 2006 Nov
1;177(9):6405-14. PubMed PMID: 17056572.

15: van Marle G, Antony JM, Silva C, Sullivan A, Power C. Aberrant cortical
neurogenesis in a pediatric neuroAIDS model: neurotrophic effects of growth
hormone. AIDS. 2005 Nov 4;19(16):1781-91. PubMed PMID: 16227785.

16: Antony JM, van Marle G, Opii W, Butterfield DA, Mallet F, Yong VW, Wallace
JL, Deacon RM, Warren K, Power C. Human endogenous retrovirus
glycoprotein-mediated induction of redox reactants causes oligodendrocyte death
and demyelination. Nat Neurosci. 2004 Oct;7(10):1088-95. PubMed PMID: 15452578.