Jürg Bähler


Professor of Systems Biology
Department of Genetics, Evolution and Environment
University College London
E-mail: j.bahler@ucl.ac.uk
Page: http://www.bahlerlab.info

Fields of interest: 

Global gene expression programs in fission yeast (S. pombe)

Regulatory networks during cell proliferation, differentiation and quiescence

Genetic diversity

Genome evolution

Cellular ageing/chronological lifespan

Non-coding RNAs

Complex interactions between genotypes, phenotypes, and the environment


Recent publications:

Pancaldi V, Saraç ÖS, Převorovský M, McLean JR, Rallis C, Gould K, Beyer A, Bähler J:
Predicting the fission yeast protein interaction network
G3, 2, (2012): 453-467.

Pancaldi V, Bähler J:
In silico characterization and prediction of global protein-mRNA interactions in yeast. 
Nucleic Acids Res, 39, (2011): 5826–5836.

Wilhelm BT, Marguerat S, Aligianni S, Codlin S, Watt S, Bähler J:
Differential patterns of intronic and exonic DNA regions with respect to transcription kinetics, nucleosome density and H3K36me3 marking in fission yeast. 
Genome Biol, 12, (2011): R82.

Lemieux C, Marguerat S, Lafontaine J, Barbezier N, Bähler J, Bachand F:
A pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein. 
Mol Cell, 44, (2011): 108–119.

Wilhelm B, Marguerat S, Goodhead I, Bähler J:
Defining transcribed regions in fission yeast using RNA-seq. 
Nature Protocols, 5, (2010): 255-266.

Pancaldi V, Schubert F, Bähler J:
Meta-analysis of genome regulation and expression variability across hundreds of environmental and genetic perturbations in fission yeast. 
Mol BioSystems, 6, (2010): 543-552.

Zhurinsky J, Leonhard K, Watt S, Marguerat S, Bähler J, Nurse P:
A Coordinated Global Control over Cellular Transcription.
Curr Biol, 404, (2010): 183-201.

Aligianni S, Lackner DH, Klier S, Rustici G, Wilhelm BT, Marguerat S, Codlin S, de Bruin RAM, Bähler J:
The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback. 
PLoS Genet, 5, (2009): e1000626.

Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J:
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. 
Nature, 453, (2008): 1239-1243.

Jeffares D, Penkett CJ, Bähler J:
Rapidly regulated genes are intron poor. 
Trends Genet 24, (2008): 375-378.

Chen D, Wilkinson CRM, Watt S, Penkett, CJ, Toone WM, Jones N, Bähler J:
Multiple pathways differentially regulate global oxidative stress responses in fission yeast.
Mol Biol Cell, 19, (2008): 308-317.

López-Maury L, Marguerat S, Bähler J:
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. 
Nat Rev Genet, 9, (2008): 583-593.

Lackner DH, Beilharz TH, Marguerat S, Mata J, Watt S, Schubert F, Preiss T, Bähler J:
A network of multiple regulatory layers shapes gene expression in fission yeast. 
Mol Cell, 26, (2007): 145-155.