Carolina Barillas-Mury

Senior Investigator
Laboratory of Malaria and Vector Research
National Institutes of Health

Fields of interest: 

Interactions between Plasmodium parasites, the gut microbiota, and mosquito midgut epithelial cells
Immune pathways that mediate antiplasmodial responses
Hemocyte differentiation and immune memory in mosquitoes
Plasmodium evasion of the mosquito immune system


Recent publications:

Oliveira GA, Lieberman J, Barillas-Mury C:
Epithelial Nitration by a Peroxidase/NOX5 System Mediates Mosquito Antiplasmodial Immunity.
Science, 335, (2012): 856-859.

Rodrigues J, Oliveira GA, Kotsyfakis M, Dixit R, Molina-Cruz A, Jochim R, Barillas-Mury C:
An Epithelial Serine Protease, AgESP, is required for Plasmodium invasion in the mosquito Anopheles gambiae.
PLoS One, 7(4), (2012): e35210.

Bahia AC, Kubota MS, Tempone AJ, Araújo HRC, Guedes BAM, Orfanó AS, Tadei WP, Ríos-Velásquez C, Han YS, Secundino NFC, Barillas-Mury C, Pimenta PFP, Traub-Csekö YM:
The JAK-STAT pathway controls Plasmodium vivax load in early stages of Anopheles aquasalis infection.
PLoS Negl Trop Dis., 5(11), (2011): e1317.

Rodrigues J, Brayner FA, Alves LC, Dixit R, Barillas-Mury C:
Hemocyte differentiation mediates innate immune memory in Anopheles gambiae Mosquitoes.
Science, 329, (2010): 1353-1355.

Gupta L, Noh JY, Jo YH, Oh SH, Kumar S, Noh MY, Lee YS, Cha SJ, Seo SJ, Kim I, Han YS, Barillas-Mury C:
Apolipophorin-III mediates antiplasmodial epithelial responses in Anopheles gambiae (G3) mosquitoes.
PloS ONE, 5(11), (2010): e15410.

Kumar S, Molina-Cruz A, Gupta L, Rodrigues J, Barillas-Mury C:
A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae.
Science, 327, (2010): 1644-1648.

Jaramillo-Gutierrez G, Rodrigues J, Ndikuyeze G, Povelones M, Molina-Cruz A, Barillas-Mury C:
Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes.
BMC Microbiology, 9(1), (2009): 154.

Gupta L, Molina-Cruz A, Kumar S, Rodrigues J, Dixit R, Zamora RE, Barillas-Mury C:
The STAT pathway mediates late phase immunity against Plasmodium in the mosquito An. gambiae.
Cell Host & Microbe, 5(5), (2009): 498-507.

Molina-Cruz A, Dejong RJ, Charles B, Gupta L, Kumar S, Jaramillo-Gutierrez G, Barillas-Mury C:
Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium.
J Biol Chem., 283(6), (2008): 3217-3223.

Waterhouse RM, Xi ZY, Kriventseva E, Meister S, Alvarez KS, Bartholomay LC, Barillas-Mury C, Bian G, Blandin S, Christensen BM, Dong Y, Jiang H, Kanost M, Koutsos AC, Levashina EA, Li J, Ligoxygakis P, MacCallum R, Mayhew GF, Mendes A, Michel K, Osta M, Paskewitz S, Shin SW, Vlachou D, Wang L, Wei W, Zheng L, Zou Z, Severson DW, Raikhel AS, Kafatos FC, Dimopoulos G, Zdobnov E, Christophides GK:
Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.
Science, 316(5832), (2007): 1738-1743.