Joseph Coyle

Eben S. Draper Professor of Psychiatry
Department of Psychiatry
McLean Hospital

Fields of interest

Developmental neurobiology, mechanisms of neuronal vulnerability, psychopharmacology, role of glutamatergic neurons in the pathophysiology of neuropsychiatric disorders.


Recent publications

Balu DT, Coyle JT.:
Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction.
Brain Res., 2011, 1392:1-7

Benneyworth MA, Roseman AS, Basu AC, Coyle JT.:
Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers.
Neurosci Lett., 2011, 488(3):267-71

Devito LM, Balu DT, Kanter BR, Lykken C, Basu AC, Coyle JT, Eichenbaum H.:
Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.
Genes Brain Behav., 2011, 10(2):210-22

Balu DT, Coyle JT.:
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.
Neurosci Biobehav Rev., 2011, 35(3):848-70

Benneyworth MA, Basu AC, Coyle JT.:
Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.
Psychopharmacology (Berl)., 2011, 213(1):143-53

Mustafa AK, Ahmad AS, Zeynalov E, Gazi SK, Sikka G, Ehmsen JT, Barrow RK, Coyle JT, Snyder SH, Doré S.:
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
J Neurosci., 2010, 30(4):1413-6

Coyle JT, Balu D, Benneyworth M, Basu A, Roseman A.:
Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.
Dialogues Clin Neurosci., 2010, 12(3):359-82

Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF.:
The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina.
Eur J Neurosci., 2009, 30(12):2308-17

Han L, Picker JD, Schaevitz LR, Tsai G, Feng J, Jiang Z, Chu HC, Basu AC, Berger-Sweeney J, Coyle JT.:
Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II.
Synapse., 2009, 63(8):625-35

Ghose S, Chin R, Gallegos A, Roberts R, Coyle J, Tamminga C.:
Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia.
Schizophr Res., 2009, 111(1-3):131-7