David Brough

Principal Investigator
Faculty of Life Sciences
University of Manchester
E-mail: david.brough@manchester.ac.uk
Page: http://www.manchester.ac.uk/research/david.brough/

Fields of interest

Sterile inflammation and the processing and secretion of interleukin-1.


Recent publications

Lopez-Castejon G, Luheshi NM, Compan V, High S, Whitehead RC, Flitsch SL, Kirov A, Prudovsky I, Swanton E, Brough D.
Deubiquitinases regulate the activity of caspase-1 and IL-1β secretion via assembly of the inflammasome.
Journal of Biological Chemistry, 2013, 288, 2721-2733.

Girard S, Brough D, Lopez-Castejon G, Giles J, Rothwell NJ, Allan SM.
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.
Glia, In press, 2013, eScholarID:186326

Denes A, Lopez-Castejon G, Brough D.
Caspase-1: Is IL-1 just the tip of the ICEberg?
Cell Death and Disease, 2012, In press, eScholarID:162137

Lopez-Castejon G, Corbett D, Goldrick M, Roberts IS, Brough D. 
Inhibition of Calpain blocks the phagosomal escape of Listeria monocytogenes.
PLoS ONE, 7, 2012, e35936. eScholarID:158024

Greenhalgh AD, Brough D, Robinson EM, Girard S, Rothwell NJ, Allan SM.
Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem driven inflammatory pathology.
Dis Model Mech, 2012, [Epub ahead of print], eScholarID:159647

Savage CD, Lopez-Castejon G, Denes A, Brough D.
NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury.
Frontiers in Immunology, 2012, 3, 288. eScholarID:170501

Lawrence CB, Brough D, Knight EM.
Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide.
Dis Model Mech, 2012 [Epub ahead of print], eScholarID:155817

Luheshi NM, Giles JA, Lopez-Castejon G, Brough D. 
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
European Journal of Immunology, 2012, 42, 716-725.

Corbett D, Wang J, Schuler S, Lopez-Castejon G, Glenn S, Brough D, Andrew PW, Cavet JS, Roberts IS.
Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes During Growth in vitro and in vivo.
Infect Immun, 2012, 80(1), 14-21.

Small BG, McColl BW, Allmendinger R, Pahle J, López-Castejón G, Rothwell NJ, Knowles J, Mendes P, Brough D, Kell DB.
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
Nat Chem Biol, 2011, 7, 902-908.

Luheshi NM, Kovacs KJ, Lopez-Castejon G, Brough D, Denes A.
Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues.
Journal of Neuroinflammation, 2011, 8, 186.

Brough D, Tyrrell PJ, Allan SM.
Regulation of interleukin-1 in acute brain injury.
Trends in Pharmacological Sciences, 2011, 32(10), 617-622.

Lopez-Castejon G, Brough D.
Understanding the mechanism of IL-1β secretion.
Cytokine Growth Factor Rev, 2011 [Epub ahead of print], eScholarID:134977