George Dimopoulos

Molecular Microbiology and Immunology
Johns Hopkins University, Bloomberg School of Public Health

Fields of interest: 

Anopheles. Aedes, molecular entomology, innate immunity, Plasmodium, dengue


Recent publications:

Sim S, Ramirez JL, Dimopoulos G:
Dengue virus infection of the Aedes aegypti salivary gland and chemosensory apparatus induces genes that modulate infection and blood-feeding behavior.
PLoS Pathogens, (2012) Accepted for publication.

Dong Y, Das S, Cirimotich CM, Souza-Neto J, McLean K, Dimopoulos G:
Engineered Anopheles immunity to Plasmodium infection.
PLoS Pathogens, 7(12), (2011): e1002458.

Cirimotich CM, Dong Y, Clayton AM, Sandiford SL, Souza-Neto JA, Mulenga M, Dimopoulos G:
Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae.
Science 332, (2011): 855-858.

Sim S, Dimopoulso G:
Dengue Virus Inhibits Immune Responses in Aedes aegypti Cells.
PLoS One, 18;5(5), (2010): e10678.

Ramirez JL, Dimopoulos G:
The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes.
Dev Comp Immunol. 34, (2010): 625-629.

Souza-Neto JA, Sim S, Dimopoulos G:
Evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense.
Proc. Natl. Acad. Sci. USA. 106(42), (2009): 17841-17846.

Erickson SA, Xi Z, Mayhew GF, Ramirez JL, Aliota MT, Christensen BM, Dimopoulos G:
Mosquito Infection Responses to Developing Filarial Worms.
PLoS Trop. Negl. Dis., 3(10), (2009): e529.

Baton LA, Robertson A, Warr E, Strand MR, Dimopoulos G:
Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection.
BMC Genomics 10(1), (2009): 257.

Dong Y, Manfredini F, Dimopoulos G:
Implication of the Mosquito Midgut Microbiota in the Defense Against Malaria Parasites.
PLoS Pathogens, 5(5), (2009): e1000423.

Dong Y, Dimopoulos G:
Anopheles fibrinogen-related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites.
J Biol Chem., 284(15), (2009): 9835-9844.

Garver L, Dong Y, Dimopoulos G:
Caspar control resistance to Plasmodium falciparum in diverse Anopheline species.
PloS Pathogens, 5(3), (2009): e1000335.