Ethan Dmitrovsky

Chair of the Pharmacology and Toxicology Department and American Cancer Society Professor
Pharmacology and Toxicology
Geisel School of Medicine at Dartmouth, USA
E-mail: Ethan.Dmitrovsky@Dartmouth.EDU

Fields of interest: 

Development and clinical implementation of microRNA-based, retinoid -based and cyclin – targeted treatments for lung cancer


Recent publications:

Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA, De Vries V, Nowak E, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Noelle RJ:
A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity.
J Exp Med., 208(9):1767-75 (2011)

Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E:
Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models.
Cancer Prev Res (Phila)., 4(6):818-28 (2011)

Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E:
Involvement of microRNAs in lung cancer biology and therapy.
Transl Res., 157(4):200-8 (2011)

Galimberti F, Thompson SL, Ravi S, Compton DA, Dmitrovsky E:
Anaphase catastrophe is a target for cancer therapy.
Clin Cancer Res., 17(6):1218-22 (2011)

Freemantle SJ, Dmitrovsky E:
Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention.
Cancer Prev Res (Phila)., 3(12):1513-8 (2010)

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E:
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.
J Clin Invest., 120(4):1298-309 (2010)

Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E:
Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe.
Clin Cancer Res., 16(1):109-20 (2010)

Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Freemantle S, Dmitrovsky E:
Blockage of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARalpha and inhibits the growth of acute promyelocytic leukemia.
Cancer Res., 70(23):9875-85 (2010)

Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E:
Uncovering growth-suppressive microRNAs in lung cancer.
Clin Cancer Res., 15(4):1177-83 (2009)

Ma Y, Fiering S, Black C, Liu X, Yuan Z, Memoli VA, Robbins DJ, Bentley HA, Tsongolis GJ, Demidenko E, Freemantle SJ, Dmitrovsky E:
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.
Proc. Natl. Acad. Sci. USA, 104(10):4089-94 (2007)