Jonathan Ewbank

Group leader
Centre d’Immunologie de Marseille-Luminy
E-mail: ewbank@ciml.univ-mrs.fr
Page: http://www.ciml.univ-mrs.fr/science/lab-jonathan-ewbank

Fields of interest: 

Innate immunity in C. elegans; natural pathogens; evolution; genetics; functional genomics; bioinformatics

 

Recent publications:

Squiban B, Belougne J, Ewbank J, Zugasti O:
Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans.
J Vis Exp., 60, (2012): e3448.

Engelmann I, Griffon A, Tichit L, Montanana-Sanchis F, Wang G, Reinke V, et al.:
A comprehensive analysis of gene expression changes provoked by bacterial and fungal infection in C. elegans.
PLoS One, 6, (2011): e19055.

Dierking K, Polanowska J, Omi S, Engelmann I, Gut M, Lembo F, et al.:
Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.
Cell Host Microbe, 9, (2011): 425-435.

Lee KZ, Kniazeva M, Han M, Pujol N, Ewbank JJ:
The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis.
Virulence, 1, (2010): 113-122.

Zugasti O, Ewbank JJ:
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis.
Nat. Immunol., 10, (2009): 249-256.

Ziegler K, Kurz CL, Cypowyj S, Couillault C, Pophillat M, Pujol N, et al.:
Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
Cell Host Microbe, 5, (2009): 341-352.

Pujol N, Zugasti O, Wong D, Couillault C, Kurz CL, Schulenburg H, et al.:
Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides.
PLoS Pathog., 4, (2008): e1000105.

Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, Goncharov A, et al.:
Distinct innate immune responses to infection and wounding in the C. elegans epidermis.
Curr. Biol., 18, (2008): 481-489.

Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank JJ:
Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection.
Genome Biol., 8, (2007): R194.

Pradel E, Zhang Y, Pujol N, Matsuyama T, Bargmann CI, Ewbank JJ:
Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans.
Proc Natl Acad Sci USA, 104, (2007): 2295-3000.