Sarah J. Freemantle

Research Assistant Professor
Department of Pharmacology and Toxicology
Geisel School of Medicine at Dartmouth, USA

Fields of interest: 

Cancer cell biology and molecular therapeutics


Recent publications:

Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E:
Involvement of microRNAs in lung cancer biology and therapy.
Transl Res., 157: 200-8 (2011)

Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ:
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.
J Biol Chem.,286: 19381-91 (2011)

Freemantle SJ, Dmitrovsky E:
Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention.
Cancer Prev Res (Phila).,3:1513-8 (2010)

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E:
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.
J Clin Invest., 120:1298-309 (2010)

Snow, G.E., Kasper, A.C., Schwarz, E., Ewings, K.E., Bee, T., Spinella, M.J., Dmitrovsky, E., and Freemantle, S.J:
Reprogramming of the Wnt signaling pathway during embryonal carcinoma cell differentiation and potential for therapeutic targeting.
BMC Cancer,9: 383 (2009)

Liu, X., Sempere, L.F., Galimberti, F., Freemantle, S.J., Black, C., Dragnev, K.H., Ma, Y., Fiering, S., Memoli, V., Li, H., DiRenzo, J., Korc, M., Cole, C., Bak, M., Kauppinen, S., and Dmitrovsky, E:
Uncovering Growth Suppressive MicroRNAs in Lung Cancer.
Clin. Canc. Res.,15: 1177-83 (2009)

Freemantle S.J., Liu X., Feng Q., Galimberti F., Blumen S., Sekula D., Kitareewan S., Dragnev K.H., Dmitrovsky E:
Cyclin degradation for cancer therapy and chemoprevention.
J Cell Biochem., 102: 869-77 (2007)

Ma, Y., Fiering, S., Black, C., Liu, X, Yuan, Z, Memoli, V.A., Robbins, D.J., Bentley, H.A., Tsongalis, G.J., Demidenko, E., Freemantle, S.J. and Dmitrovsky, E:
Transgenic Cyclin E Triggers Dysplasia and Multiple Pulmonary Adenocarcinomas.
Proc. Natl. Acad. Sci. USA.,104: 4089-94 (2007)

Sempere L.F., Freemantle S.J., Pitha-Rowe I., Moss E., Dmitrovsky E., Ambros, V.
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.
Genome Biology, 5(R13):1-11 (2004)

Freemantle, S.J., Kerley, J.S., Olsen, S.L., Gross, R.H., and Spinella, M.J:
Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embyronal carcinoma cells.
Oncogene,21: 2880-2889 (2002)