Thomas Gillingwater

Personal Chair of Neuroanatomy
Centre for Integrative Physiology & Euan MacDonald Centre for Motor Neurone Disease Resarch
University of Edinburgh

Fields of interest:

Spinal Muscular Atrophy (SMA); common mechanisms regulating degeneration of synaptic connections across a range of different neurodegenerative conditions; novel neuroprotective treatment strategies; novel in vitro screening platforms for modeling neurodegenerative diseases using human stem cells; axon-glial interactions.

Recent publications:

Mutsaers CA, Wishart TM, Lamont DJ, Riessland M, Schreml J, Comley LH, Murray LM, Parson SH, Lochmüller H, Wirth B, Talbot K, Gillingwater TH.:
Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.
Hum Mol Genet., 2011, 20:4334-44

Gillingwater TH.:
Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?
Br J Pharmacol., 2011 Aug 1

Sleigh JN, Gillingwater TH, Talbot K.:
The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.
Dis Model Mech., 2011, 4:457-67

Comley LH, Fuller HR, Wishart TM, Mutsaers CA, Thomson D, Wright AK, Ribchester RR, Morris GE, Parson SH, Horsburgh K, Gillingwater TH.:
ApoE isoform-specific regulation of regeneration in the peripheral nervous system.
Hum Mol Genet., 2011, 20:2406-21

Comley LH, Wishart TM, Baxter B, Murray LM, Nimmo A, Thomson D, Parson SH, Gillingwater TH.:
Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research.
PLoS One., 2011, 6:e17639

Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S.:
Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.
Nat Commun., 2011, 2:214

Murray LM, Comley LH, Gillingwater TH, Parson SH.:
The response of neuromuscular junctions to injury is developmentally regulated.
FASEB J., 2011, 25:1306-13

Wright AK, Wishart TM, Ingham CA, Gillingwater TH.:
Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.
PLoS One., 2010, 5:e15108

Wishart TM, Huang JP, Murray LM, Lamont DJ, Mutsaers CA, Ross J, Geldsetzer P, Ansorge O, Talbot K, Parson SH, Gillingwater TH.:
SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.
Hum Mol Genet., 2010, 19:4216-28

Murray LM, Gillingwater TH, Parson SH:
Using mouse cranial muscles to investigate neuromuscular pathology in vivo.
Neuromuscul Disord., 2010, 20:740-3