Gaynor Smith

Post-doctoral Research Fellow
Neuroregeneration laboratories – Mclean hospital
Harvard Medical School

Fields of interest: 

Parkinson’s disease, Huntington’s disease, Transplantation, L-DOPA induced dyskinesia, Graft induced dyskinesia, Gene therapy, Alpha synuclein, neuro-inflammation.


Recent publications:

Lane EL, Daly CS, Smith GA, Dunnett SB:
Context-driven behavioural changes in L-dopa-induced abnormal involuntary movements in the 6-OHDA lesioned rat.
Neurobiol. Dis., 42(1), (2011): 99-107.

Torres EM, Lane EL, Heuer A, Smith GA, Murphy E, Dunnett SB:
Improvement of the 6-Hydroxydopamine lesion of the median forebrain bundle by modification of the stereotaxic coordinates.
J. Neurosci. Meth., 200(1), (2011): 29-35.

Heuer A, Smith GA, Lelos MJ, Lane EL, Dunnett SB:
Comprehansive Behavioural Evaluation of Striatal, MFB and Nigral Unilateral 6-ohda Lesioned Mice (Part I).
Behav. Brain Res.,226(1), (2011): 281-292.

Smith GA, Heuer A, Dunnett SB, Lane EL:
Unilateral 6-ohda lesions of the Striatum, MFB and Nigra in Mice (Part II). Analysis of the Behavioural and Histological Hallmarks of L-dopa Induced Dyskinesia.
Behav. Brain Res.,(2011) E pub.

Smith GA, Breger L, Lane EL, Dunnett SB:
The Pharmacological Modulation of Amphetamine-Induced Dyskinesia in the Grafted Hemi-Parkinsonian Model.
Neuropharmacology, In press.

Smith GA, Dunnett SB, Lane EL:
Amphetamine-Induced Dyskinesia in the transplanted Hemi-Parkinsonian rat – response to pharmacological challenges.
Behavioural brain research, In Press.

Lane EL, Smith GA:
Understanding Graft Induced Dyskinesia.
Regen. Med., 5(5), (2010): 787-797.

Smith GA, Murphy E, Dunnett SB, Lane EL:
Toxin-based Models of Parkinson’s disease.
Handbook of Laboratory Animal Science (Volume II) 3rd Ed. CRC Press U.S.A. (2011).

Smith GA, Heuer A:
The 6-OHDA Lesioned Mouse Model of Parkinson’s Disease.
Contemporary Models of Movement Disorders.Springer/Humana PressSpringer/Humana Press. London (2011).