Ian Holt

Researcher, PhD
Wolfson Centre for Inherited Neuromuscular Disease
Robert Jones and Agnes Hunt Orthopaedic Hospital
E-mail: ian.holt@rjah.nhs.uk
Page: http://www.glennmorris.org.uk/mono.htm


Fields of interest:

Neuromuscular disease, producing monoclonal antibodies as highly-specific research tools for analysis of molecular mechanisms in the pathogenesis of human genetic disease and for improved diagnosis



Recent publications:

Tome S., Holt I., Edelmann W., Morris G. E., Munnich A., Pearson C. E., Gourdon G.:

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice

PLoS Genet. 2009; 5(5): e1000482.


Holt I., Jacquemin V., Fardaei M., Sewry C. A., Butler-Browne G. S., Furling D., Brook J. D., Morris G. E.:

Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle

Am. J. Pathol. 2009; 174(1): 216-227.


Dansithong W., Wolf C. M., Sarkar P., Paul S., Chiang A., Holt I., Morris G. E., Branco D., Sherwood M. C., Comai L., Berul C. I., Reddy S.:

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features

PLoS One 2008; 3(12): e3968.


HoltI., Mittal S., Furling D., Butler-Browne G. S., Brook J. D., Morris G. E.:

Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles

Genes Cells 2007; 12(9): 1035-1048.


Wolstencroft E. C., Simic G., thi Man N., Holt I., Lam le T., Buckland P. R., Morris G. E.:

Endosomal location of dopamine receptors in neuronal cell cytoplasm

J. Mol. Histol. 2007; 38(4): 333-340.


HoltI., Nguyen T. M., Wehnert M., Morris G. E.:

Lamin A/C assembly defects in Emery-Dreifuss muscular dystrophy can be regulated by culture medium composition

Neuromuscul. Disord. 2006; 16(6): 368-373.


Pham Y. C., Man N., Holt I., Sewry C. A., Pall G., Johnson K., Morris G. E.:

Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies

J. Cell Biochem. 2005; 95(5): 990-1001.


Holt I., Ostlund C., Stewart C. L., Man N., Worman H. J., Morris G. E.:

Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo

J. Cell Sci. 2003; 116(Pt 14): 3027-3035.


Wilkinson F. L., Holaska J. M., Zhang Z., Sharma A., Manilal S., Holt I., Stamm S., Wilson K. L., Morris G. E.:

Emerin interacts in vitro with the splicing-associated factor, YT521-B

Eur. J. Biochem. 2003; 270(11): 2459-2466.


HoltI., Clements L., Manilal S., Morris G. E.:

How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?

Biochem. Biophys. Res. Commun. 2001; 287(5): 1129-1133.