Isabelle Couillin

UMR7355 Immunologie et Neurogenetique Experimentales & Moleculaires (INEM) (ex IEM-UMR6218) Experimental and Molecular Immunology and Neurogenetics
CNRS and University of Orleans

Fields of interest

Inflammation, Danger signals, Inflammasomes, IL-1, IL-33, IL-17, BAFF, Cathepsins, Purinergic signaling, MyD88, Lung fibrosis, COPD. Asthma


Recent publications

Gombault A, Baron L and Couillin I.
ATP release and purinergic signaling in NLRP3 inflammasome activation
Front Immunol.2012; 3:414. doi: 10.3389/fimmu.2012.00414. Epub 2013 Jan 8.

Riteau N, Baron L, Villeret B, Guillou N, Savigny F, Ryffel B, Rassendren F, Le Bert M, Gombault A, Couillin I.
ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation.
Cell Death Dis. 2012; 3: e403

Rigato C, Swinnen N, Buckinx R, Couillin I, Mangin JM, Rigo JM, Legendre P, Le Corronc H.
Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion.
J Neurosci. 2012 Aug 22; 32(34): 11559-11573.

Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B.
Inflammasome-IL-1-Th17 response in allergic lung inflammation.
J Mol Cell Biol. 2012;4 :3-10

Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, Di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I. IL-1 and IL-23
Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis.
PLoS ONE 2011;6: e23185

Maillet I, Schnyder-Candrian S, Couillin I, Quesniaux VF, Erard F, Moser R, Fleury S, Kanda A, Dombrowicz D, Szymkowski DE, Ryffel B.
Allergic Lung Inflammation is Mediated by Soluble TNF and Attenuated by Dominant-negative TNF Biologics.
Am J Respir Cell Mol Biol. 2011 Feb

Doisne JM, Soulard V, Bécourt C, Amniai L, Henrot P, Havenar-Daughton C, Blanchet C, Zitvogel L, Ryffel B, Cavaillon JM, Marie JC, Couillin I, Benlagha K.
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
J Immunol. 2010 Dec

Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J.
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1αand IL-1β.
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. Epub 2010 Oct 25.PMID: 20974980

Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, Ryffel B, Couillin I.
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis.
Am. J. Respir. Crit. Care Med. 2010;182:774-83

Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brûle S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F.
IL-17A-Producing {gamma}{delta} T and Th17 Lymphocytes Mediate Lung Inflammation but Not Fibrosis in Experimental Silicosis.
J Immunol. 2010 Apr 26. [Epub ahead of print]PMID: 20421647

Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B.
IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.
J Immunol. 2009; 183: 8195-202

Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I.
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
Am. J. Respir. Crit. Care Med. 2009; 179:903-13

Doz E, Noulin N, Boichot E, Guénon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I.
Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent.
J. Immunol. 2008; 180: 1169-78

Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I.
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
J Clin Invest.2007 Dec; 117(12): 3786-99.