Escoubas Jean-Michel

Diversity, Genome and Interactions Microorganisms-Insects (INRA-UM2)
CNRS : Centre National de la Recherche Scientifique

Fields of interest: 

Invertebrate immunity (mollusks and insects)

Host pathogen interactions (at molecular level)

Immunosuppression and avoidance strategies

Evolution and biologic adaptations


Recent publications:

Duvic B, Jouan V, Essa N, Girard P-A, Pages S, Abi Khattar Z, Volkoff A-N, Givaudan A, Destoumieux-Garzon D, Escoubas J-M:
Cecropins as a marker of Spodoptera frugiperda immunosuppression during entomopathogenic bacterial challenge.
Journal of Insect Physiology (2012), in press.

Varela Chavez C, Jubelin G, Courties G, Gomard A, Taïeb F, Ginibre N, Oswald E, Givaudan A, Zumbihl R, Escoubas JM:
The cyclomodulin Cif of Photorhabdus luminescens inhibits proliferation of insect cells and triggers host cell death by apoptosis.
Microbes and Infection, 12 (14-15), (2010): 1208-1218.

Costa SCP, Varela Chavez C, Jubelin G, Givaudan A, Escoubas JM, Brehelin M, Zumbihl R:
Recent insight into the pathogenicity mechanisms of the emergent pathogen Photorhabdus asymbiotica.
Microbes and Infection, 12(3), (2010): 182-189.

Abi Khattar Z, Kallassy M, Rejasse A, Destoumieux-Garzon D, Escoubas JM, Sanchis V, Lereclus D, Givaudan A, Nielsen-Leroux C, Gaudriault S:
The dlt operon of Bacillus cereus is Required for Resistance to Cationic Antimicrobial Peptides and Virulence in Insects.
J. Bact. 191(22), (2009): 7063-7073.

Destoumieux-Garzon D, Brehelin M, Bulet P, Boublik Y, Girard PA, Baghdiguian S, Zumbihl R, Escoubas JM:
Spodoptera frugiperda X-tox protein, an immune related defensin rosary, has lost the function of ancestral defensins.
PloS One 4(8), (2009): e6795.

Jubelin G, Varela Chavez C, Taieb F, Banfield MJ, Samba- Louaka A, Nobe R, Nougayrède JP, Zumbihl R, Givaudan A, Escoubas JM, Oswald E:
Cycle inhibiting factors (CIFs) are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogens.
PloS One, 4(3), (2009): e4855.

Girard P-A, Boublik Y, Wheat CW, Volkoff A-N, Cousserans F, Brehélin M, Escoubas J-M:
X-tox: an atypical defensin derived family of immune related protein specific to Lepidoptera.
Dev. Comp. Immunol., 32 (5), (2008): 575-584.

Montagnani C, Labreuche Y, Escoubas J-M:
Cg-IB, a new member of the IB protein family characterized in the Pacific oyster Crassostrea gigas.
Dev. Comp. Immunol., 32(3), (2008): 182-190.

Gonzalez M, Gueguen Y, Destoumieux-Garzón D, Romestand R, Fievet J, Pugnière M, Roquet F, Escoubas J-M, Vandenbulcke F, Levy O, Sauné L, Bulet P, Bachère E:
First evidence of a Bactericidal Permeability Increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI.
Proc. Natl. Acad. Sci. USA., 104(45), (2007): 17759-17764.

Montagnani C, Avarre JC, de Lorgeril J, Quiquand M, Boulo V, Escoubas J-M:
First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway
Dev. Comp. Immunol., 31, (2007): 1-11.