JESTIN Jean-Luc

Fields of interest:

Enzymes; Macromolecular Evolution; Biological Chemistry

Short bio-sketch:

PhD in Chemistry, Université Pierre et Marie Curie, Paris, France (1994)

Habilitation in Biochemistry, Université Pierre et Marie Curie, Paris, France (2002)

Post-doctoral work at the Laboratory of Molecular Biology and the Centre of Protein Engineering, Cambridge, United Kingdom (1996-1998)

Tenured researcher at Institut Pasteur, Paris, France (1999-2015)

Selected publications

Jestin J.L., Tailor-made biocatalysts: combining thermodynamics, organic synthesis, molecular biology, biochemistry and microbiology for the design of enzyme selections. Comput. Struct. Biotech. J. 2012, 2, 1-6.

Jestin J.L., Pecorari F., Protein design. In “Foldamers: structure, properties and applications”, Wiley-VCH, Weinheim, 2007.

Vichier-Guerre S., Ferris S., Auberger N., Mahiddine K., Jestin J.L., A population of thermostable reverse transcriptases evolved from Thermus aquaticus DNA polymerase I by phage display. Angewandte Chemie International Edition 2006, 45, 6133-6137.

Jestin J.L., Vichier-Guerre S., How to broaden enzyme substrate specificity: Strategies, implications and applications. Research in Microbiology 2005, 156, 961-966.

Jestin J.L., Kaminski P.A., Directed enzyme evolution and selections for catalysis based on product formation. Journal of Biotechnology 2004, 113, 85-103.