James Sleigh

University of Oxford, Division of Clinical Neurology
E-mail: james.sleigh@ndcn.ox.ac.uk
Page: http://www.clneuro.ox.ac.uk/team/researchers/james-sleigh

Fields of interest:

neurological disease, neuromuscular disease, neurodegeneration, motor neuron, neuromuscular junction, spinal muscular atrophy, Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis, stem cells, iPSC, genetics.

Publications:

Sleigh JN, Grice SJ, Burgess RW, Talbot K, Cader MZ:
Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice,
Hum. Mol. Genet., 2014 [Epub ahead of print]

Sleigh JN, Barreiro-Iglesias A, Oliver PL, Biba A, Becker T, Davies KE, Becker CG, Talbot K:
Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy,
Hum. Mol. Genet., 2014, 23, 855-869

Turner BJ, Alfazema N, Sheean RK, Sleigh JN, Davies KE, Horne MK, Talbot K:
Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice,
Neurobiol. Aging., 2014, 35, 906-915

Bogdanik LP, Sleigh JN, Tian C, Samuels ME, Bedard K, Seburn KL, Burgess RW:
Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease,
Dis. Model Mech., 2013, 6, 780–792

Sleigh JN, Grice SJ, Davies KE, Talbot K:
Spinal muscular atrophy at the crossroads of basic science and therapy,
Neuromuscul. Disord., 2013, 23, 96

Grice SJ, Sleigh JN, Liu JL, Sattelle DB:
Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics,
Bioessays., 2011, 33, 956-965

Sleigh JN, Gillingwater TH, Talbot K.
The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy,
Dis. Model Mech., 2011, 4, 457-467

Sleigh JN, Buckingham SD, Esmaeili B, Viswanathan M, Cuppen E, Westlund BM, Sattelle DB:
A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds,
Hum. Mol. Genet., 2011, 20, 245-260

Sleigh JN, Sattelle DB:
C. elegans models of neuromuscular diseases expedite translational research,
Transl. Neurosci., 2010, 1, 214-227

Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D,Artavanis-Tsakonas S, Hart AC:
Conserved genes act as modifiers of invertebrate SMN loss of function defects,
PLoS Genet., 2010, 6, e1001172