Leszek Kaczmarek

Professor of Neurobiology
Head of the Laboratory for Molecular Neurobiology
Nencki Institute, Warsaw, Poland
E-mail: l.kaczmarek@nencki.gov.pl
Page: http://neurogene.nencki.gov.pl

Fields of interest

Brain-mind connection and its molecular and cellular underpinnings. Synaptic plasticity, learning and memory and neuropsychiatric disorders. Central amygdala in appetitive learning and addiction.

Recent publications

Stefaniuk M., Beroun A., Lebitko T., Markina O., Leski S., Meyza K., Grzywacz A., Samochowiec J., Samochowiec A., Radwanska K., Kaczmarek L. Matrix metalloproteinase-9 and synaptic plasticity in the central amygdala in control of alcohol seeking behavior. Biological Psychiatry, in press.

van der Kooij M. , Fantin M. , Rejmak E., Grosse J., Zanoletti O., Fournier C., Ganguly K., Kalita K., Kaczmarek L., Sandi C. Role for MMP-9 in stress-induced down-regulation of nectin-3 in hippocampal CA1 and associated behavioral alterations. Nature Commun., 5: 4995, 2014.

Stawarski M., Rutkowska-Wlodarczyk I., Zeug A., Bijata M., Madej H., Kaczmarek L., Wlodarczyk J. Genetically encoded biosensor for imaging MMP-9 activity. Biomaterials, 35: 1402-1410, 2014.

Janusz A., Milek J., Perycz M., Pacini L., Bagni C., Kaczmarek L., Dziembowska M. The Fragile X Mental Retardation Protein regulates Matrix Metalloproteinase 9 mRNA at synapses.  J. Neurosci., 33: 18234–1824, 2013.

Knapska E., Lioudyno V., Kiryk A., Gorkiewicz T., Mikosz M., Michaluk P., Gawlak M., Chaturvedi M., Mochol G., Balcerzyk M., Wojcik D.K., Wilczynski G.M., Kaczmarek L. Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. J. Neurosci., 33: 14591–14600, 2013.

Dziembowska M., Milek J., Janusz A., Rejmak E., Romanowska E., Gorkiewicz T., Tiron A., Bramham C., Kaczmarek L. Activity-dependent local translation of matrix metalloproteinase-9. J. Neurosci., 32: 14538 –14547, 2012.

Knapska E., Macias M., Mikosz M., Nowak A., Owczarek D., Wawrzyniak M., Pieprzyk M.,  Cymerman I.A., Werka T., Sheng M., Maren S., Jaworski J., Kaczmarek L., Functional anatomy of neural circuits regulating fear and extinction. Proc. Natl. Acad. Sci. USA, 42: 17093-17098, 2012.