Ke Ning

Non-clinical Lecturer in Translational Neuroscience
Department of Neuroscience
Sheffield Institute of Translational Neuroscience, University of Sheffield

Fields of interest

Use of viral vector-mediated gene therapy in treatment of neurodegenerative diseases (SMA, ALS).


Recent publications

Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo SW, Valori CF, Cox L, Sharrack B, Wharton SB, Ince PG, Shaw PJ, Azzouz M.:
Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.
Brain., 2011, 134:506-17

Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo SW, Valori CF, Cox L,Sharrack B, Wharton SB, Ince PG, Shaw P & Azzouz M.:
PTEN/AKT pathway linked to motor neuron survival in human SOD1-related amyotrophyic lateral sclerosis.
Brain, 2010, In press.

Valori CF, Ning K, Wyles M, Mead R., Grierson A., Shaw P., Azzouz M.:
Systemic Delivery of scAAV9 expressing SMN Prolongs Survival in a Model of Spinal Muscular Atrophy.
Science Translational Medicine, 2010, 2(35):35ra42

Ning K, Drepper C, Valori C, Wyles M, Higginbottom A, Shaw P, Azzouz M, Sendtner M.:
PTEN depletion rescues axonal growth defect and improve survival in SMN-deficient motor neurons.
Human Molecular Genetics, 2010, 19(16):3159-68

Ning K., Miller L.C., Laidlaw H. A., Watterson K.R., Gallagher J., Sutherland C. and Ashford M.L.J.:
Leptin dependent phosphorylation of PTEN mediates actin restructing and actvation of ATP-sensitive K+ channels.
The Journal of Biological Chemistry, 2009,284(14):9331-40

Valori CF, Ning K., Wyles M. and Azzouz M.:
Applications of Lentiviral Vectors for biology and gene therapy of neurological disorders.
Current Gene Therapy, 2008, 8(6):406-18

Li L, El-Hayek YH, Liu B, Chen Y, Gomez E, Wu X, Ning K, Li L, Chang N, Zhang L, Zhengguo W, Hu X, Wan Q.:
Direct-current Electrical Field Guides Neuronal Stem/progenitor Cell Migration.
Stem Cells., 2008, 26(8):2193-200

Ning, K., Miller, L., Burgess, L.A., Laidlaw HA, Perera, N., Downes, C.P., Leslie, N.R.,& Ashford, M.L.J.:
A novel leptin signaling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic ß-cells.
The EMBO Journal, 2006,25(11):2377-2387

Liu, B., Liao, M., Mielke, J.G., Ning, K., Chen, Y., Li, L., EI-Hayek, Y.H., Gomez, E., Zukin, R.S., Fehlings, M.G., Wan, W.:
Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites.
The Journal of Neuroscience, 2006, 26(20):5309-5319

Mirshamsi S., Laidlaw H.A., Ning, K., Anderson E., Burgess L.A., Gray A., Sutherland C., Ashford M.L.J.:
Stimulation of PI3K by leptin and insulin leads to actin reognization and KATP activation in arcuate nucleus neurons.
BMC Neuroscience, 2004,5, 54