Rajesh Khanna

Assistant Professor of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
Indiana University School of Medicine, USA
E-mail: khanna5@iupui.edu
Page: http://pharmtox.iusm.iu.edu/faculty/rajesh-khanna-ph-d/khanna-lab-people/

Fields of interest:

Regulation of calcium channels by interacting proteins; CRMP regulation of calcium and sodium channels; CRMP-2 and calcium channels: a new network in neurofibromatosis type I; functional analyses of the antiepileptic drug lacosamide and its derivatives on sodium channels and in pain

Recent publications:

Wang Y, Khanna R.:
Voltage-gated calcium channels are not affected by the novel anti-epileptic drug lacosamide.
Transl Neurosci., 2011, 2:13-22

Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A, White FA, Zamponi GW, Brustovetsky N, Chen J, Khanna R.:
Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2).
J Biol Chem., 2011 Aug 9

Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R.:
Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.
Channels (Austin), 2011, 5:449-56

Wang Y, Wilson SM, Brittain JM, Ripsch MS, Salomé C, Park KD, White FA, Khanna R, Kohn H.:
Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain.
ACS Chem Neurosci., 2011, 2:317-322

Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, Cheon BM, Due MR, Brustovetsky T, Ashpole NM, Hudmon A, Meroueh SO, Hingtgen CM, Brustovetsky N, Ji RR, Hurley JH, Jin X, Shekhar A, Xu XM, Oxford GS, Vasko MR, White FA, Khanna R.:
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.
Nat Med., 2011, 17:822-9

Wang Y, Park KD, Salome C, Wilson SM, Stables JP, Liu R, Khanna R, Kohn H.:
Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.
ACS Chem Neurosci., 2011, 2:90-106

Wang Y, Brittain JM, Wilson SM, Khanna R.:
Emerging roles of collapsin response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission.
Commun Integr Biol., 2010, 3:172-5

Wang Y, Brittain JM, Jarecki BW, Park KD, Wilson SM, Wang B, Hale R, Meroueh SO, Cummins TR, Khanna R.:
In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation.
J Biol Chem., 2010, 285:25296-307

Wang Y, Brittain JM, Wilson SM, Hingtgen CM, Khanna R.:
Altered calcium currents and axonal growth in Nf1 haploinsufficient mice.
Transl Neurosci., 2010, 1:106-114