Lars Knutsen

Drug Discovery Director and Project Manager
Discovery Pharm Consulting LLC
Discovery Pharm, West Chester, PA, USA

Fields of interest

Medicinal chemistry; drug discovery and development.


Recent publications

Hudkins RL, Raddatz R, Tao M, Mathiasen JR, Aimone LD, Becknell NC, Prouty CP, Knutsen LJ, Yazdanian M, Moachon G, Ator MA, Mallamo JP, Marino MJ, Bacon ER, Williams M.:
Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.
J Med Chem., 2011, 54(13):4781-92

Knutsen LJ.:
Drug discovery management, small is still beautiful: Why a number of companies get it wrong.
Drug Discov Today., 2011, 16(11-12):476-84

Gillespie RJ, Adams DR, Bebbington D, Benwell K, Cliffe IA, Dawson CE, Dourish CT, Fletcher A, Gaur S, Giles PR, Jordan AM, Knight AR, Knutsen LJ, Lawrence A, Lerpiniere J, Misra A, Porter RH, Pratt RM, Shepherd R, Upton R, Ward SE, Weiss SM, Williamson DS.:
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.
Bioorg Med Chem Lett., 2008, 18(9):2916-9

Knutsen LJ, Hobbs CJ, Earnshaw CG, Fiumana A, Gilbert J, Mellor SL, Radford F, Smith NJ, Birch PJ, Russell Burley J, Ward SD, James IF.:
Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.
Bioorg Med Chem Lett., 2007, 17(3):662-7

Haldeman M, Vieira B, Winer F, Knutsen LJ.:
Exploration tools for drug discovery and beyond: applying SciFinder to interdisciplinary research.
Curr Drug Discov Technol., 2005, 2(2):69-74