Cynthia A. Lemere

Associate Professor of Neurology, PhD
Department of Neurology
Harvard Medical School


Fields of interest:

Aging process, neurodevelopmental disorders (Down syndrome, etc.), Alzheimer’s disease, Parkinson disease, neuroimmunology


Recent publications:

Peng Y., Sun J., Hon S., Nylander A. N., Xia W., Feng Y., Wang X., Lemere C. A.:
L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease
J. Neurosci. 2010; 30(24): 8180-8189.

Lemere C. A., Masliah E.:
Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
Nat. Rev. Neurol. 2010; 6(2): 108-119.

Shankar G. M., Leissring M. A., Adame A., Sun X., Spooner E., Masliah E., Selkoe D. J., Lemere C. A., Walsh D. M.:
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life
Neurobiol. Dis. 2009; 36(2): 293-302.

Peng Y., Xing C., Xu S., Lemere C. A., Chen G., Liu B., Wang L., Feng Y., Wang X.:
L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats
Eur. J. Pharmacol. 2009; 621(1-3): 38-45.

Kadokura A., Yamazaki T., Lemere C. A., Takatama M., Okamoto K.:
Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology
Neuropathology 2009; 29(5): 566-573.

Kadokura A., Yamazaki T., Kakuda S., Makioka K., Lemere C. A., Fujita Y., Takatama M., Okamoto K.:
Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration
Neurosci. Lett .2009; 463(1): 87-92.

Lemere C. A.:
Developing novel immunogens for a safe and effective Alzheimer's disease vaccine
Prog. Brain Res. 2009; 175: 83-93.

Shankar G. M., Li S., Mehta T. H., Garcia-Munoz A., Shepardson N. E., Smith I., Brett F. M., Farrell M. A., Rowan M. J., Lemere C. A., Regan C. M., Walsh D. M., Sabatini B. L., Selkoe D. J.:
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Nat. Med. 2008; 14(8): 837-842.

Maier M., Peng Y., Jiang L., Seabrook T. J., Carroll M. C., Lemere C. A.:
Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
J. Neurosci. 2008; 28(25): 6333-6341.

Klyubin I., Betts V., Welzel A. T., Blennow K., Zetterberg H., Wallin A., Lemere C. A., Cullen W. K., Peng Y., Wisniewski T., Selkoe D. J., Anwyl R., Walsh D. M., Rowan M. J.:
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
J. Neurosci. 2008; 28(16): 4231-4237.