Gillian Murphy

Department of Oncology
University of Cambridge

Fields of interest: 

metalloproteinase, tumour microenvironment, angiogenesis


Recent publications:

Tape CJ, Willems SH, Dombernowsky SL, Stanley PL, Fogarasi M, Ouwehand W, McCafferty J, Murphy G. (2011): 
Cross-domain inhibition of TACE ectodomain.
Proc Natl Acad Sci U S A. 108(14):5578-83.

Willems SH, Tape CJ, Stanley PL, Taylor NA, Mills IG, Neal DE, McCafferty J, Murphy G. (2010):
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17
Biochem J.428(3):439-50           

Murphy G (2008): 
The ADAMs: signalling scissors in the tumour microenvironment.
Nat Rev Cancer. 8(12):932-41.

Lee MH, Atkinson S, Murphy G.(2007): 
Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1.
J Biol Chem 282:6887-98.