Najib El-Sayed

Associate Professor
Department of Cell Biology and Molecular Genetics
University of Maryland, USA
E-mail: elsayed@umd.edu
Page: http://www.najibelsayed.org/

Field of interests:

Genome Sequencing and Analysis

Comparative Genomics of Human Pathogens

Functional Proteomics – Elucidation of kinetoplastid interactomes and host-pathogen protein-protein interactions

Functional Genomics – Characterization of a novel surface protein family (MASP) in Trypanosoma cruzi

The Human Microbiome and Disease

 

Recent publications:

Choi J, El-Sayed NM:
Functional genomics of trypanosomatids. 
Parasite Immunol., 34(2-3), (2012): 72-79.

Simões MC, Lee J, Djikeng A, Cerqueira GC, Zerlotini A, da Silva-Pereira RA, Dalby AR, LoVerde P, El-Sayed NM, Oliveira G:
Identification of Schistosoma mansoni microRNAs. 
BMC Genomics, 12, (2011): 47.

Severance S, Rajagopal A, Rao AU, Cerqueira GC, Mitreva M, El-Sayed NM, Krause M, Hamza I:
Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. 
PLoS Genet., 6(7), (2010): e1001044.

Joseph SJ, Fernández-Robledo JA, Gardner MJ, El-Sayed NM, Kuo CH, Schott EJ, Wang H, Kissinger JC, Vasta GR:
The Alveolate Perkinsus marinus: biological insights from EST gene discovery.
BMC Genomics, 11, (2010): 228.

Ittiprasert W, Miller A, Myers J, Nene V, El-Sayed NM, Knight M:
Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni. 
Mol Biochem Parasitol., 169(1), (2010): 27-39.

Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens  A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu  W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM:
The genome of the blood fluke Schistosoma mansoni. 
Nature, 460(7253), (2009): 352-358.

Bartholomeu DC, Cerqueira GC, Leão AC, daRocha WD, Pais FS, Macedo C, Djikeng  A, Teixeira SM, El-Sayed NM:
Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma  cruzi. 
Nucleic Acids Res., 37(10), (2009): 3407-3417.

Waisberg M, Lobo FP, Cerqueira GC, Passos LK, Carvalho OS, El-Sayed NM, Franco GR:
Schistosoma mansoni: Microarray analysis of gene expression induced by host sex. 
Exp Parasitol., 120(4), (2008): 357-363.

Bringaud F, Ghedin E, El-Sayed NM, Papadopoulou B:
Role of transposable elements in trypanosomatids. 
Microbes Infect., 10(6), (2008): 575-581.

Cerqueira GC, Bartholomeu DC, DaRocha WD, Hou L, Freitas-Silva DM, Machado CR, El-Sayed NM, Teixeira SM:
Sequence diversity and evolution of multigene families in Trypanosoma cruzi.
Mol Biochem Parasitol., 157(1), (2008): 65-72.

Bringaud F, Müller M, Cerqueira GC, Smith M, Rochette A, El-Sayed NM, Papadopoulou B, Ghedin E:
Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. 
PLoS Pathog. 3(9), (2007): 1291-1307.

Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway M, Koo H, Salzberg SL, Schobel S, Pertea M, Pop M, White O, Barton GJ, Carlow CK, Crawford  MJ, Daub J, Dimmic MW, Estes CF, Foster JM, Ganatra M, Gregory WF, Johnson NM, Jin J, Komuniecki R, Korf I, Kumar S, Laney S, Li BW, Li W, Lindblom TH, Lustigman S, Ma D, Maina CV, Martin DM, McCarter JP, McReynolds L, Mitreva M, Nutman TB, Parkinson J, Peregrín-Alvarez JM, Poole C, Ren Q, Saunders L, Sluder AE, Smith K, Stanke M, Unnasch TR, Ware J, Wei AD, Weil G, Williams DJ, Zhang Y,  Williams SA, Fraser-Liggett C, Slatko B, Blaxter ML, Scott AL:
Draft genome of the filarial nematode parasite Brugia malayi. 
Science, 317(5845), (2007): 1756-1760.

Haas BJ, Berriman M, Hirai H, Cerqueira GG, Loverde PT, El-Sayed NM:
Schistosoma mansoni genome: closing in on a final gene set. 
Exp Parasitol., 117(3), (2007): 225-228.