Alexander Nikitin

Leader, Cornell Stem Cell Program / Associate Professor of Pathology
Department of Biomedical Sciences
Cornell University

Fields of interest: 

The role of stem cell compartment in carcinogenesis

Studies of epithelial ovarian cancer pathogenesis


Recent publications:

Gu X, Vedvyas Y, Chen X, Kaushik T, Hwang CI, Hu X, Nikitin AY, Jin MM:
Monoclonal antibody against ephrin-B2 for detection of tumor and neovasculature, and gene delivery application.
PLOS One, 7, (2012):e30680.

Migone FF, Ren Y, Cowan RG, Harman RM, Nikitin AY, Quirk SM:
Dominant activation of the Hedgehog signaling pathway alters development of the female reproductive tract.
Genesis, 50, (2012):28-40.

Hwang C-I, Choi J, Zhou Z, Flesken-Nikitin A, Tarakhovsky A, Nikitin AY:
MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF.
Cell Cycle, 10, (2011):3834-3840.

Cheng C-Y, Nikitin AY:
Neuroendocrine cells: potential cells of origin for small cell lung carcinoma.
Cell Cycle, 10, (2011):3629-3630.

Hwang C-I, Matoso A, Corney DC, Flesken-Nikitin A, Körner S, Wang W, Boccaccio C, Thorgeirsson SS, Comoglio PM, Hermeking H, Nikitin AY:
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.
Proc. Natl. Acad. Sci. USA., 108, (2011):14240-14245.

Bolon B, Altrock B, Barthold SW, Baumgarth N, Besselsen D, Boivin G, Boyd KL, Brayton C, Cardiff RD, Couto S, Eaton KA, Foreman O, Griffey SM, La Perle K, Lairmore MD, Liu C, Meyerholz DK, Nikitin AY, Schoeb TR, Schwahn D, Sellers RS, Sundberg JP, Tolwani R, Valli VE, Zink MC:
Advancing translational research.
Science, 331, (2011):1516-1517.

Sun H, Wang Y, Chinnam M, Zhang X, Hayward SW, Fosrter BA., Nikitin AY, Willis M, Goodrich DW:
An E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.
Proc. Natl. Acad. Sci. USA., 108, (2011):704-709.

Sundberg JP, Ward JM, HogenEsch H, Nikitin AY, Treuting PM, Macauley JB, Schofield PN:
Training pathologists in mouse pathology.
Vet. Pathology, 49(2), (2010):393-7.

Choi J, Curtis S, Roy DM, Flesken-Nikitin A, Nikitin AY:
Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency.
Am. J. Pathology., 177, (2010):2645-2658.

Cheng L, Zhou Z, Flesken-Nikitin A, Toshkov IA, Wang W, Camps J, Ried T, Nikitin AY:
Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.
Oncogene. 29, (2010):5700-50711.

Williams RM, Flesken-Nikitin A, Ellenson LH, Connolly DC, Hamilton TC, Nikitin AY, Zipfel WR:
Strategies for high resolution imaging of epithelial ovarian cancer by laparoscopic nonlinear microscopy.
Translational Oncology. 3, (2010):181-194.

Corney DC, Hwang C, Matoso A, Vogt M, Flesken-Nikitin A, Godwin AK, Kamat AA, Sood AK, Hermeking H, Ellenson LH, Nikitin AY
Frequent downregulation of miR-34 family in human ovarian cancers.
Clin. Cancer Res. 16, (2010): 1119–1128.