Giulio M. Pasinetti

Professor of Neurology, Psychiatry, Geriatrics and Palliative Medicine, Neuroscience, MD, PhD
Mount Sinai School of Medicine


Fields of interest:

Neuronal degeneration in Alzheimer's disease and model system



Recent publications:

Gong B., Chen F., Pan Y., Arrieta-Cruz I., Yoshida Y., Haroutunian V., Pasinetti G. M.:

SCF(Fbx2) -E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function

Aging Cell 2010; 9(6): 1018-1031.


DixonR. A., Pasinetti G. M.:
Flavonoids and isoflavonoids: from plant biology to agriculture and neuroscience

Plant. Physiol. 2010; 154(2): 453-457.


Pfleger C. M., Wang J., Friedman L., Vittorino R., Conley L. M., Ho L., Fivecoat H. C., Pasinetti G. M.:
Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy

Int. J. Alzheimers Dis. 2010; 2010.


Pedrini S., Thomas C., Brautigam H., Schmeidler J., Ho L., Fraser P., Westaway D., Hyslop P. S., Martins R. N., Buxbaum J. D., Pasinetti G. M., Dickstein D. L., Hof P. R., Ehrlich M. E., Gandy S.:

Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology

Mol. Neurodegener. 2009; 4: 40.


Qin W., Haroutunian V., Katsel P., Cardozo C. P., Ho L., Buxbaum J. D., Pasinetti G. M.:
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia

Arch. Neurol. 2009; 66(3): 352-361.


Ferruzzi M. G., Lobo J. K., Janle E. M., Cooper B., Simon J. E., Wu Q. L., Welch C., Ho L., Weaver C., Pasinetti G. M.:

Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease

J. Alzheimers Dis. 2009; 18(1): 113-124.

Zhao W., Wang J., Ho L., Ono K., Teplow D. B., Pasinetti G. M.:
Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization

J. Alzheimers Dis. 2009; 16(1): 49-57.


Ono K., Condron M. M., Ho L., Wang J., Zhao W., Pasinetti G. M., Teplow D. B.:
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity

J. Biol. Chem. 2008; 283(47): 32176-32187.


Wang J., Ho L., Zhao W., Ono K., Rosensweig C., Chen L., Humala N., Teplow D. B., Pasinetti G. M.:

Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

J. Neurosci. 2008; 28(25): 6388-6392.


Takahashi M., Uchikado H., Caprotti D., Weidenheim K. M., Dickson D. W., Ksiezak-Reding H., Pasinetti G. M.:
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles

J. Neuropathol. Exp. Neurol. 2006; 65(12): 1157-1169.