Damien D. Pearse

Professor, PhD
The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies
Department of Neurological Surgery
The Miami Project to Cure Paralysis
The Interdisciplinary Stem Cell Institute, The Neuroscience Program
The University of Miami Miller School of Medicine
E-mail: DPearse@med.miami.edu
Page: http://www.themiamiproject.org/research/faculty/damien-pearse/

 

Fields of interest:

Preventing progressive tissue damage following the initial mechanical trauma through the application of pharmacological or biological neuroprotectants

Overcoming the physical impediment of the injury cyst through the implantation of exogenous cells or by harnessing endogenous cellular repair mechanisms

The promotion of axon regeneration by the stimulation of intracellular signaling pathways that are important in the initiation and/or maintainence of axon growth

 

Recent publications:

Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.
Knott EP, Assi M, Rao SN, Ghosh M, Pearse DD.
Int J Mol Sci. 2017 Mar 24;18(4). pii: E696. doi: 10.3390/ijms18040696. Review.

Safety of Autologous Human Schwann Cell Transplantation in Subacute Thoracic Spinal Cord Injury.
Anderson KD, Guest JD, Dietrich WD, Bunge MB, Curiel R, Dididze M, Green BA, Khan A, Pearse DD, Saraf-Lavi E, Widerström-Noga E, Wood P, Levi AD.
J Neurotrauma. 2017 Mar 21. doi: 10.1089/neu.2016.4895. [Epub ahead of print]

Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model.
Maggio DM, Singh A, Iorgulescu JB, Bleicher DH, Ghosh M, Lopez MM, Tuesta LM, Flora G, Dietrich WD, Pearse DD.
Int J Mol Sci. 2017 Jan 25;18(2). pii: E245. doi: 10.3390/ijms18020245.

Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration.
Rao SN, Pearse DD.
Front Mol Neurosci. 2016 Jun 8;9:33. doi: 10.3389/fnmol.2016.00033. Review.

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW.
Glia. 2016 Oct;64(10):1788-94. doi: 10.1002/glia.23007. Review.

PDE4B as a microglia target to reduce neuroinflammation.
Pearse DD, Hughes ZA.
Glia. 2016 Oct;64(10):1698-709. doi: 10.1002/glia.22986. Review.

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines.
Ghosh M, Xu Y, Pearse DD.
J Neuroinflammation. 2016 Jan 13;13:9. doi: 10.1186/s12974-015-0463-9.

Does being female provide a neuroprotective advantage following spinal cord injury?
Datto JP, Yang J, Dietrich WD, Pearse DD.
Neural Regen Res. 2015 Oct;10(10):1533-6. doi: 10.4103/1673-5374.165213. Review.

Acute Putrescine Supplementation with Schwann Cell Implantation Improves Sensory and Serotonergic Axon Growth and Functional Recovery in Spinal Cord Injured Rats.
Iorgulescu JB, Patel SP, Louro J, Andrade CM, Sanchez AR, Pearse DD.
Neural Plast. 2015;2015:186385. doi: 10.1155/2015/186385.

The Comparative Utility of Viromer RED and Lipofectamine for Transient Gene Introduction into Glial Cells.
Rao S, Morales AA, Pearse DD.
Biomed Res Int. 2015;2015:458624. doi: 10.1155/2015/458624.

Therapeutic Hypothermia in Spinal Cord Injury: The Status of Its Use and Open Questions.
Wang J, Pearse DD.
Int J Mol Sci. 2015 Jul 24;16(8):16848-79. doi: 10.3390/ijms160816848. Review.

Peptide-functionalized polymeric nanoparticles for active targeting of damaged tissue in animals with experimental autoimmune encephalomyelitis.
Führmann T, Ghosh M, Otero A, Goss B, Dargaville TR, Pearse DD, Dalton PD.
Neurosci Lett. 2015 Aug 18;602:126-32. doi: 10.1016/j.neulet.2015.06.049.

MASH1/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNS.
Williams RR, Venkatesh I, Pearse DD, Udvadia AJ, Bunge MB.
PLoS One. 2015 Mar 9;10(3):e0118918. doi: 10.1371/journal.pone.0118918.

The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
Ghosh M, Aguirre V, Wai K, Felfly H, Dietrich WD, Pearse DD.
Biomed Res Int. 2015;2015:308461. doi: 10.1155/2015/308461.

Female Rats Demonstrate Improved Locomotor Recovery and Greater Preservation of White and Gray Matter after Traumatic Spinal Cord Injury Compared to Males.
Datto JP, Bastidas JC, Miller NL, Shah AK, Arheart KL, Marcillo AE, Dietrich WD, Pearse DD.
J Neurotrauma. 2015 Aug 1;32(15):1146-57. doi: 10.1089/neu.2014.3702.

The role of the serotonergic system in locomotor recovery after spinal cord injury.
Ghosh M, Pearse DD.
Front Neural Circuits. 2015 Feb 9;8:151. doi: 10.3389/fncir.2014.00151. Review.

Schwann cell transplantation for spinal cord injury repair: its significant therapeutic potential and prospectus.
Kanno H, Pearse DD, Ozawa H, Itoi E, Bunge MB.
Rev Neurosci. 2015;26(2):121-8. doi: 10.1515/revneuro-2014-0068. Review.