Marina R. Picciotto

Professor of Psychiatry, Neurobiology and Pharmacology
Department of Neuroscience
Yale University School of Medicine

Fields of interest

  • animal models of psychiatric illness
  • acetylcholine and nicotinic acetylcholine receptors in depression and appetite – drug discovery of nicotinic partial agonists and antagonists as novel antidepressant drugs

Recent publications

Jung, Y.-W., Hsieh, L.S., Lee, A.M., Zhou, Z., Coman, D., Heath, C.J., Hyder, F., Mineur, Y.S., Yuan, Q., Goldman, D., Bordey, A. and Picciotto, M.R. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. (2016) Nature Neuroscience, 19(7):905-14. PMC4925298

McClure-Begley, T.D., Esterlis, I., Stone, K.L., Lam, T.T., Grady, S.R., Colangelo, C.M., Lindstrom, J.M., Marks, M.J., Picciotto, M.R. (2016) Evaluation of the nicotinic acetylcholine receptor-associated proteome at baseline and following nicotine exposure in human and mouse cortex. eNeuro DOI: 10.1523/ENEURO.0166-16.2016. PMC4985585

Lewis, A.S., Oberleitner, L., Morgan, P.T., Picciotto, M.R. and McKee, S.A. Association of cigarette smoking with interpersonal and self-directed violence in a large community-based sample. (2016) Nicotine & Tobacco Res, 18(6):1456-62. (PMC in process)

Mineur, Y.S., Fote, G.M., Blakeman, S., Cahuzac, E.L.M., Newbold, S.A. and Picciotto, M.R. Multiple nicotinic acetylcholine receptor subtypes in the mouse amygdala regulate affective behaviors and response to social stress. (2016) Neuropsychopharmacology, 41(6):1579-87. PMC4832019

Lewis, A.S., Mineur, Y.S., Smith, P.H., Cahuzac, L.M. and Picciotto, M.R. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. (2015) Biochem Pharmacol, 97(4):488-97. PMC4600457

Mineur, Y.S., Bentham, M.P., Plantenga, M.E., McKee, S.A. and Picciotto, M.R. Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos reactivity and paired-pulse ratio in male and female mice. (2015) Psychopharmacology, 232(19):3539-49. PMC4561580

Zhou, WL, Gao, X.-B. and Picciotto, M.R. (2015) Acetylcholine acts through nicotinic receptors to enhance the firing rate of a subset of hypocretin neurons in the mouse hypothalamus through distinct presynaptic and postsynaptic mechanisms, eNeuro, 2(1); DOI: 10.1523/ENEURO.0052-14.2015. PMC4551500

Mineur, Y.S., Einstein, E.B., Bentham, M.P., Wigestrand, M.B., Blakeman, S., Newbold, S.A. and Picciotto, M.R. Expression of the 5HT1a serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. (2015) Neuropsychopharmacology, 40(4):938-46. PMC4330507