Jacques Pouyssegur

Emeritus CNRS Research Director
Institute of Research on Cancer and Aging (IRCAN)
University of Nice, France
E-mail: pouysseg@unice.fr

Fields of interest: 

Control of cell division – pH control Mechanisms – Hypoxia signaling and nutrient sensing – Tumor microenvironment – Metabolism and Cancer. 

 

Recent publications:

Parks S, Chiche J, Pouysségur, J
Disrupting Proton Dynamics and metabolism for novel cancer therapy
Nature Reviews Cancer, 2012, (invited).

Le FlochR, ChicheJ, Marchiq I, Naïken, Ilc K, MurrayC, CritchlowS, RouxD, SimonMP and Pouysségur J(2011)
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Proc. Natl. Acad. Sci (USA).2011, 108, 16663-8.

Brahimi-Horn, C and Pouysségur, J
Hypoxia and Energetic Tumor Metabolism
Curr. Op. Genet. Dev., 2011, 21, 67-72.

Mazure, N. and  Pouysségur, J
Hypoxia-induced autophagy: cell death or cell survival?
Curr. Op. Cell Biol., 2010, 22, 177-180. 

Chiche J, Ilc K, Laferrière J, Trottier E, Dayan F, Mazure NM, Brahimi-Horn MC, Pouysségur J
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
Cancer Res. (2009) 69, 358-368.

Kroemer, G. and Pouysségur, J
Tumor cell metabolism; cancer’s Achilles heel.
Cancer Cell 13, 2008, 472-82. 

Ginouvès A, Ilc K, Macías N, Pouysségur J, Berra E.
PHDs overactivation during chronic hypoxia “desensitizes” HIFalpha and protects cells from necrosis
Proc Natl Acad SciUSA.(2008) 105, 4745-50.

Brahimi-Horn, C, Chiche J,  Pouyssegur J.
Hypoxia Signalling Controls Metabolic Demand.
Curr. Op. Cell Biol. (2007) 19, 223-9.

Pouysségur, J. Dayan, F. and Mazure, N.
Hypoxia signaling in Cancer and approaches to enforce Tumour Regression.
Nature, 2006,441, 437-443. 

Berra, E., Ginouvès, A. and Pouysségur J
The Hypoxia-Inducible-Factor hydroxylases bring fresh air into Hypoxia Signaling.
EMBO Rep, 2006, 7: 41-5.