Payam Rezaie

Reader in Neuropathology and Head of Discipline (Brain & Behavioural Sciences)
Life, Health and Chemical Sciences
The Open University, UK

Fields of interest

Neurobiology and pathophysiology of the cerebral cortex in autism

Pathology and pathogenesis of Huntington’s disease

Development, differentiation and functional roles of microglia

Normal and abnormal development of the human fetal brain

Infectious and neurodegenerative diseases (incl. Creutzfeldt-jakob disease, Alzheimer’s disease, lysosomal storage disorders and Huntington’s disease) 


Recent publications

Ojo B., Rezaie P., Gabbott P.L., Davies H., Colyer F., Cowley T.R., Lynch M., Stewart M.G.:
Age-related changes in the hippocamnpus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL.
Brain Behav. Immun. Oct 2, 2011 [Epub ahead of print]

Ojo B., Rezaie P., Gabbott P.L., Cowley T.R., Medvedev N.I., Lynch M.A., Stewart M.G.:
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus.
Exp. Neurol. 2011; 232(2): 318-328.

Dallerac G.M., Vatsavayai S.C., Cummings D.M., Milnerwood A.J., Peddie C.J., Evans K.A., Walters S.W., Rezaie P., Hirst M.C., Murphy K.P.:
Impaired long-term potentiation in the prefrontal cortex of Huntington’s disease mouse models: rescue by D1 dopamine receptor activation.
Neurodegener. Dis. 2011; 8(4): 230-239.

Subileau E. A., Rezaie P., Davies H. A., Colyer F. M., Greenwood J., Male D. K., Romero I. A.:
Expression of chemokines and their receptors by human brain endothelium: implications for multiple sclerosis
J. Neuropathol. Exp. Neurol. 2009; 68(3): 227-240.

Afonso P. V., Ozden S., Cumont M. C., Seilhean D., Cartier L., Rezaie P., Mason S., Lambert S., Huerre M., Gessain A., Couraud P. O., Pique C., Ceccaldi P. E., Romero I. A.:
Alteration of blood-brain barrier integrity by retroviral infection
PLoS Pathog. 2008; 4(11): e1000205.

Cheung K. K., Mok S. C., Rezaie P., Chan W. Y.:
Dynamic expression of Dab2 in the mouse embryonic central nervous system
BMC Dev. Biol. 2008; 8: 76.

Ulfig N., Steinbrecher A., Stoltenburg-Didinger G., Rezaie P.:
Differential activation of mononuclear phagocytes in cerebellar malformation associated with Walker-Warburg syndrome
Neuropathology 2008; 28(3): 333-340.

Rezaie P., Al-Sarraj S.:
Vacuolar degeneration affecting brain macrophages/microglia in variant CJD: a report on two cases
Acta Neuropathol. 2007; 114(6): 651-658.

Vatsavayai S. C., Dallerac G. M., Milnerwood A. J., Cummings D. M., Rezaie P., Murphy K. P., Hirst M. C.:
Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington’s disease with delayed phenotypic onset
Brain Res. Bull. 2007; 72(2-3): 98-102.

Milnerwood A. J., Cummings D. M., Dallerac G. M., Brown J. Y., Vatsavayai S. C., Hirst M. C., Rezaie P., Murphy K. P.:
Early development of aberrant synaptic plasticity in a mouse model of Huntington’s disease
Hum. Mol. Genet. 2006; 15(10): 1690-1703.

Kay G. W., Palmer D. N., Rezaie P., Cooper J. D.:
Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis
Brain Pathol. 2006; 16(2): 110-116.

Oswald M. J., Palmer D. N., Kay G. W., Shemilt S. J., Rezaie P., Cooper J. D.:
Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6)
Neurobiol. Dis. 2005; 20(1): 49-63.

Rezaie P., Pontikis C. C., Hudson L., Cairns N. J., Lantos P. L.:
Expression of cellular prion protein in the frontal and occipital lobe in Alzheimer’s disease, diffuse Lewy body disease, and in normal brain: an immunohistochemical study
J. Histochem. Cytochem. 2005; 53(8): 929-940.