Steven E. Arnold

Director, Geriatric Psychiatry Program Director, Cellular and Molecular Neuropathology Program
Departments of Psychiatry and Neurology
University of Pennsylvania


Fields of interest:

Cellular and molecular neurobiology of schizophrenia and mood disorders, aging and neurodegenerative dementias


Recent publications:

Buchman A. S., Boyle P. A., Wilson R. S., James B. D., Leurgans S. E., Arnold S. E., Bennett D. A.:

Loneliness and the rate of motor decline in old age: the rush memory and aging project, a community-based cohort study

BMC Geriatr. 2010; 10: 77.


Hamilton R., Patel S., Lee E. B., Jackson E. M., Lopinto J., Arnold S. E., Clark C. M., Basil A., Shaw L. M., Xie S. X., Grady M. S., Trojanowski J. Q.:

Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology

Ann. Neurol. 2010; 68(4): 535-540.


Geser F., Robinson J. L., Malunda J. A., Xie S. X., Clark C. M., Kwong L. K., Moberg P. J., Moore E. M., Van Deerlin V. M., Lee V. M., Arnold S. E., Trojanowski J. Q.:

Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness

Arch. Neurol. 2010; 67(10): 1238-1250.


Hu W. T., Chen-Plotkin A., Arnold S. E., Grossman M., Clark C. M., Shaw L. M., McCluskey L., Elman L., Karlawish J., Hurtig H. I., Siderowf A., Lee V. M., Soares H., Trojanowski J. Q.:

Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease

Acta Neuropathol. 2010; 120(3): 385-399.


Hu W. T., Chen-Plotkin A., Grossman M., Arnold S. E., Clark C. M., Shaw L. M., McCluskey L., Elman L., Hurtig H. I., Siderowf A., Lee V. M., Soares H., Trojanowski J. Q.:

Novel CSF biomarkers for frontotemporal lobar degenerations

Neurology 2010; 119(6): 669-678.


Soetanto A., Wilson R. S., Talbot K., Un A., Schneider J. A., Sobiesk M., Kelly J., Leurgans S., Bennett D. A., Arnold S. E.:

Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans

Arch. Gen. Psychiatry 2010; 67(5): 448-457.


Arnold S. E., Lee E. B., Moberg P. J., Stutzbach L., Kazi H., Han L. Y., Lee V. M., Trojanowski J. Q.:

Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease

Ann. Neurol. 2010; 67(4): 462-469.


Trojanowski J. Q., Arnold S. E., Karlawish J. H., Brunden K., Cary M., Davatzikos C., Detre J., Gaulton G., Grossman M., Hurtig H., Jedrziewski K., McCluskey L., Naylor M., Polsky D., Schellenberg G. D., Siderowf A., Shaw L. M., Van Deerlin V., Wang L. S., Werner R., Xie S. X., Lee V. M.:

Design of comprehensive Alzheimer's disease centers to address unmet national needs

Alzheimers Dement. 2010; 6(2): 150-155.


Yu C. E., Bird T. D., Bekris L. M., Montine T. J., Leverenz J. B., Steinbart E., Galloway N. M., Feldman H., Woltjer R., Miller C. A., Wood E. M., Grossman M., McCluskey L., Clark C. M., Neumann M., Danek A., Galasko D. R., Arnold S. E., Chen-Plotkin A., Karydas A., Miller B. L., Trojanowski J. Q., Lee V. M., Schellenberg G. D., Van Deerlin V. M.:

The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration

Arch. Neurol. 2010; 67(2): 161-170.


Tang J., LeGros R. P., Louneva N., Yeh L., Cohen J. W., Hahn C. G., Blake D. J., Arnold S. E., Talbot K.:

Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression

Hum. Mol. Genet. 2009; 18(20): 3851-3863.