David B. Sattelle

Head of Neural Signalling, Professor of Molecular Neurobiology
MRC Functional Genomics Unit, Department of Physiology Anatomy and Genetics
University of Oxford
E-mail: david.sattelle@dpag.ox.ac.uk
Page: http://www.mrcfgu.ox.ac.uk/research/david-sattelle

Fields of interest:

Identifying the diverse functions of nicotinic acetylcholine receptors and determining their roles in nervous system and neuromuscular diseases and as drug targets

Generating and studying invertebrate models (Caenorhabditis elegans andDrosophila melanogaster) of human diseases such as Alzheimer's Disease (AD), Congenital Myasthenia Syndrome (CMS) and Spinal Muscular Atrophy (SMA)


Recent publications:

Sleigh J. N., Buckingham S. D., Esmaeili B., Viswanathan M., Cuppen E., Westlund B. M., Sattelle D. B.:
A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds
Hum Mol Genet 2011; 20(2): 245-260.

Jones A. K., Buckingham S. D., Sattelle D. B.:
Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons
Trends Pharmacol Sci 2010; 31(10): 455-462.

Moloney A., Sattelle D. B., Lomas D. A., Crowther D. C.:
Alzheimer's disease: insights from Drosophila melanogaster models
Trends Biochem Sci 2010; 35(4): 228-235..

Sattelle D. B., Buckingham S. D., Akamatsu M., Matsuda K., Pienaar I. S., Jones A. K., Sattelle B. M., Almond A., Blundell C. D.:
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors
Biochem Pharmacol 2009; 78(7): 836-843.

Buckingham S. D., Higashino Y., Sattelle D. B.:
Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone
Invert Neurosci 2009; 9(2): 85-89.

Jones A. K., Buckingham S. D., Brown L. A., Sattelle D. B.:
Alternative splicing of the Anopheles gambiae nicotinic acetylcholine receptor, Agamalphabeta9, generates both alpha and beta subunits
Invert Neurosci 2009; 9(2): 77-84.

Buckingham S. D., Jones A. K., Brown L. A., Sattelle D. B.:
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection
Pharmacol Rev 2009; 61(1): 39-61.

Buckingham S. D., Sattelle D. B.:
Fast, automated measurement of nematode swimming (thrashing) without morphometry
BMC Neurosci 2009; 10: 84.

Matsuda K., Kanaoka S., Akamatsu M., Sattelle D. B.:
Diverse actions and target-site selectivity of neonicotinoids: structural insights Mol Pharmacol 2009; 76(1): 1-10.

Williamson S. M., Robertson A. P., Brown L., Williams T., Woods D. J., Martin R. J., Sattelle D. B., Wolstenholme A. J.:
The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits
PLoS Pathog 2009; 5(7): e1000517.