Sigfrido Scarpa

Senior Scientist
Of Surgery “Pietro Valdoni”
University of Rome “La Sapienza”
Journal Editor of Epigenetics of Neurodegenerative Diseases

Fields of interest: 

Epigenetics, Neurosciences, DNA methylation, S-adenosylmethionine metabolism, homocysteine, epigenetic therapy

Recent publications:

Fuso A, Nicolia V, Ricceri L, Cavallaro RA, Isopi E, Mangia F, Fiorenza MT, Scarpa S:
“S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice”
Neurobiol Aging, 2012

Fuso A, Cavallaro RA, Nicolia V, Scarpa S:
PSEN1 Promoter Demethylation in Hyperhomocysteinemic TgCRND8 Mice is the Culprit, not the Consequence.
Curr Alzheimer Res., 2012

Fuso A, Nicolia V, Pasqualato A, Fiorenza MT, Cavallaro RA, Scarpa S:
“Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency”.
Neurobiol Aging, 32(2):187-99 (2011)

Fuso A, Scarpa S:
One-carbon metabolism and Alzheimer’s disease:
is it all a methylation matter?”
Neurobiology of Aging,32(7): 1192-5. (2011)

Sigfrido Scarpa:
“ Epigenetics and nutrition: B-vitamin deprivation and its impact on brain amyloid”.
Springer: Chapter on Handbook of Behaviour, Diet and  Nutrition, accepted

Cavallaro RA, Fuso A, Nicolia V,Scarpa S:
“S-Adenosylmethionine Prevents Oxidative Stress and Modulates Glutathione Metabolism in TgCRND8 Mice Fed with B Vitamin Deficient Diet.”
J Alzheimers Dis., 2010

Fuso A, Nicolia V, Cavallaro RA,Scarpa S:
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer’s disease models.
J Nutr Biochem.,22 (3): 242-251 (2010)

Fuso A, Ferraguti G, Grandoni F, Ruggeri R, Scarpa S, Strom R and Lucarelli M:
“Early Demethylation of non-CpG, CpC-rich, elements in the myogenin 5’-flanking region: A priming effect on the spreading of active demethylation.”
Cell Cycle, 9(19) (2010)

BorroM, CavallaroRA, GentileG, NicoliaV, FusoA, SimmacoM, ScarpaS:
“One-carbon metabolism alteration affects brain proteome profile in a mouse model of Alzheimer’s disease”
Journal of Alzheimer Disease, 22(4):1257-68 (2010)

Milagre I, Joao Nunes M, Moutinho M, Rivera I, Fuso A, Scarpa S, Joao Gama M and Rodrigues E:
“Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination”.
Journal of Alzheimer Disease, 22(4):1209-21 (2010)