Stephen Y. Chan, MD, PhD

Assistant Professor of Medicine/Associate Physician
Cardiovascular Medicine
Brigham and Women's Hospital/Harvard Medical School

Fields of interest

network biology, pulmonary vascular disease, hypoxia, microRNA


Recent publications

S.Y. Chan, J. Loscalzo
Pathogenic Mechanisms of Pulmonary Arterial Hypertension
J. Mol.Cell. Cardiol. 44 (1), 14-30 (2008)

S.Y. Chan,Y.Y. Zhang, C. Hemann, C.E. Mahoney, J.L. Zweier, J. Loscalzo
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.
Cell Metab. 10 (4); 273-284 (2009)

S.Y. Chan, J. Loscalzo
MicroRNA-210: A Unique and Pleiotropic Hypoxamir.
Cell Cycle. 9(6): 1072-1083 (2010)

A.L.Baggish, A. Hale, R.B. Weiner, G.D. Lewis, D. Systrom, F. Wang, T.J. Wang, S.Y. Chan
Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training.
J. Physiol. 589(Pt 16): 3983-3994 (2011)

V.N. Parikh, R.C. Jin, S. Rabello, N. Gulbahce, K. White, A. Hale, K.A. Cottrill, R.S. Shaik, A.B. Waxman,  Y.Y. Zhang, B.A. Maron, J.C. Hartner, Y. Fujiwara, S.H. Orkin, K.J. Haley, A.L. Barabasi, J. Loscalzo, S.Y. Chan
MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach.
Circulation.125(12): 1520-1532 (2012)

B.A. Maron, Y.Y. Zhang, K. White, S.Y. Chan, D.E. Handy, C.E. Mahoney, J. Loscalzo, J.A. Leopold
Aldosterone Inactivates the Endothelin-B Receptor Via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension.
Circulation. 126(8):963-974 (2012)

S.Y. Chan, K.W. White, J. Loscalzo
Deciphering the Molecular Basis of Human Cardiovascular Disease through Network Biology.
Curr. Opin. Cardiol. 27(3): 202-209 (2012)

S.Y. Chan, J. Loscalzo
The Emerging Paradigm of Network Medicine in the Study of Human Disease.
Circ. Res. 111(3):359-374 (2012)

A. Hale, K.W. White, S.Y. Chan
Hypoxamirs in Pulmonary Hypertension: Breathing New Life into Pulmonary Vascular Research.
Cardiovasc. Diag. Ther. 2(3):200-212 (2012)

K. White, J. Loscalzo, S.Y. Chan
Holding Our Breath: The Emerging and Anticipated Roles of MicroRNA in Pulmonary Hypertension.
Pulm. Circ. 2(3):278-290 (2012)