Stephen Clark


WestCHEM Professor and Head of School
School of Chemistry
University of Glasgow

Fields of interest: 

Total synthesis of complex bioactive natural product targets

Use of metal carbenoids in organic synthesis

Applications of ring-closing metathesis reactions in synthesis

Asymmetric oxidation and amination reactions

Biomimetic synthesis of alkaloids


Recent publications: 

Clark, J. S.; Berger, R.; Hayes, S. T.; Thomas, L. H.; Morrison, A. J.; Gobbi L:
Enantioselective Total Syntheses of Three Cladiellins (Eunicellins): A General Approach to the Entire Family of Natural Products,
Angew. Chem., Int. Ed. Eng., Vol. 49, (2010), pp. 9867–9870.

Clark, J. S.; Baxter C. A.; Dossetter, A. G.; Poigny, S.; Castro, J. L.; Whittingham, W. G.:
Stereoselective Construction of the Tricyclic Core of Neoliacinic Acid,
J. Org. Chem., Vol. 73, (2008), pp. 1040–1055.

Clark, J. S.; Conroy, J.; Blake, A. J.:
Rapid Synthesis of the A–E Fragment of Ciguatoxin CTX3C,
Org. Lett.Vol. 9, (2007), pp. 2091–2094.

Clark, J. S.; Grainger, D. M.; Ehkirch, A. A.-C.; Blake, A. J.; Wilson, C.:
Synthesis of the Fused Polyether Core of Hemibrevetoxin B by Two-directional Ring-closing Metathesis,
Org. Lett.Vol. 9, (2007), pp. 1033–1036. 

Clark, J. S.; Hayes, S. T.; Wilson, C.; Gobbi, L.:
A Concise Total Synthesis of (±)-Vigulariol,
Angew. Chem., Int. Ed. Eng. Vol. 46, (2007), pp. 437–440.

Clark, J. S.; Roche, C.:
Tuneable Asymmetric Copper-Catalyzed Allylic Amination and Oxidation Reactions,
Chem. Comm.,(2005), pp. 5175–5177.

Clark, J. S.; Kimber, M. C.; Robertson J.; McErlean, C. S. P; Wilson, C:
Rapid Two-directional Synthesis of the F–J Fragment of the Gambieric Acids by Iterative Double Ring-Closing Metathesis
Angew. Chem., Int. Ed. Eng. Vol. 44, (2005), pp. 6157–6162.

Clark, J. S.; Myatt, J; Wilson, C; Roberts, L; Walshe, N.:
Exploration of the Biomimetic Synthesis of Indole-Diterpene Mycotoxins: An Unexpected Cascade Reaction during the Attempted Synthesis of Emindole SB,
Chem. Comm.2003, 1546–1547.

Clark, J. S.; Hamelin, O.:
Synthesis of Polycyclic Ethers by Two-Directional Double Ring-closing Metathesis,
Angew. Chem., Int. Ed. Eng.Vol. 39, (2000), pp. 372–374.Angew. Chem. Vol. 112, (2000), pp. 80–382.

Clark, J. S.; Kettle, J. G.:
Synthesis of Brevetoxin Sub-units by Sequential Ring-closing Metathesis and Hydroboration,  Tetrahedron LettersVol. 38, (1997), pp. 123–126.