Nenad Šestan

Associate Professor, MD, PhD
Department of Neurobiology and Kavli Institute for Neuroscience
Yale University School of Medicine


Fields of interest:

How neuronal identities and synaptic circuits form during development, and how they have changed during the evolution of the mammalian brain


Recent publications:

Bilguvar K., Ozturk A. K., Louvi A., Kwan K. Y., Choi M., Tatli B., Yalnizoglu D., Tuysuz B., Caglayan A. O., Gokben S., Kaymakcalan H., Barak T., Bakircioglu M., Yasuno K., Ho W., Sanders S., Zhu Y., Yilmaz S., Dincer A., Johnson M. H., Bronen R. A., Kocer N., Per H., Mane S., Pamir M. N., Yalcinkaya C., Kumandas S., Topcu M., Ozmen M., Sestan N., Lifton R. P., State M. W., Gunel M.:

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

Nature 2010; 467(7312): 207-210.


Fertuzinhos S., Krsnik Z., Kawasawa Y. I., Rasin M. R., Kwan K. Y., Chen J. G., Judas M., Hayashi M., Sestan N.:

Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia

Cereb. Cortex 2009; 19(9): 2196-2207.


Ros H., Sachdev R. N., Yu Y., Sestan N., McCormick D. A.:

Neocortical networks entrain neuronal circuits in cerebellar cortex

J. Neurosci. 2009; 29(33): 10309-10320.


Johnson M. B., Kawasawa Y. I., Mason C. E., Krsnik Z., Coppola G., Bogdanovic D., Geschwind D. H., Mane S. M., State M. W., Sestan N.:

Functional and evolutionary insights into human brain development through global transcriptome analysis

Neuron 2009; 62(4): 494-509.


Stillman A. A., Krsnik Z., Sun J., Rasin M. R., State M. W., Sestan N., Louvi A.:

Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome

J. Comp. Neurol. 2009; 513(1): 21-37.


Hashimoto-Torii K., Torii M., Sarkisian M. R., Bartley C. M., Shen J., Radtke F., Gridley T., Sestan N., Rakic P.:

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex

Neuron 2008; 60(2): 273-284.


Kwan K. Y., Lam M. M., Krsnik Z., Kawasawa Y. I., Lefebvre V., Sestan N.:

SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons

Proc. Natl. Acad. Sci. U S A 2008; 105(41): 16021-16026.


Britanova O., de Juan Romero C., Cheung A., Kwan K. Y., Schwark M., Gyorgy A., Vogel T., Akopov S., Mitkovski M., Agoston D., Sestan N., Molnar Z., Tarabykin V.:

Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex

Neuron 2008; 57(3): 378-392.


Breunig J. J., Silbereis J., Vaccarino F. M., Sestan N., Rakic P.:

Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus

Proc. Natl. Acad. Sci. U S A 2007; 104(51): 20558-20563.


Rasin M. R., Gazula V. R., Breunig J. J., Kwan K. Y., Johnson M. B., Liu-Chen S., Li H. S., Jan L. Y., Jan Y. N., Rakic P., Sestan N.:

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors

Nat. Neurosci. 2007; 10(7): 819-827.