Eva Sykova

Professor, MD, PhD
Department of Neuroscience
Charles University
E-mail: sykovae@gmail.com


Fields of interest:

  • Origin, mechanisms and pathophysiological significance of ionic changes in the extracellular space
  • Membrane properties, volume regulation and function of glial cells
  • Extracellular space volume and geometry – factors affecting diffusion in the CNS
  • Stem cells and biomaterials in neurodegenerative diseases, stroke and spinal cord injury


Recent publications:

CICANIC M, SYKOVA E, VARGOVA L. (2012) Bral1: “Superglue” for the extracellular matrix in the brain white matter. Int J Biochem Cell Biol. 44(4):596-9.

DUBSKÝ M, KUBINOVÁ S, SIRC J, VOSKA L, ZAJÍČEK R, ZAJÍCOVÁ A, LESNÝ P, JIRKOVSKÁ A, MICHÁLEK J, MUNZAROVÁ M, HOLÁŇ V, SYKOVÁ E. (2012) Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing. J Mater Sci Mater Med. 23(4):931-41.

KUBINOVÁ S, SYKOVÁ E. (2012) Biomaterials combined with cell therapy for treatment of spinal cord injury. Regen Med. 7(2):207-24.

PÊGO AP, KUBINOVA S, CIZKOVA D, VANICKY I, MAR FM, SOUSA MM, SYKOVA E. (2012) Regenerative Medicine for the Treatment of Spinal Cord Injury: More than Just Promises? J Cell Mol Med. 16(11):2564-82

AMEMORI T, ROMANYUK N, JENDELOVA P, HERYNEK V, TURNOVCOVA K, PROCHAZKA P, KAPCALOVA M, COCKS G, PRICE J, SYKOVA E. (2013) Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat. Stem Cell Res Ther. 4(3):68.

FOROSTYAK S, JENDELOVA P, SYKOVA E. (2013) The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications. Biochimie. 95(12):2257-70.

SYKOVA E, FOROSTYAK S. (2013) Stem cells in regenerative medicine. Laser Ther. 22(2):87-92.

FOROSTYAK S, HOMOLA A, TURNOVCOVA K, SVITIL P, JENDELOVA P, SYKOVA E. (2014) Intrathecal delivery of mesenchymal stromal cells protects the structure of altered perineuronal nets in SOD1 rats and amends the course of ALS. Stem Cells.  32(12):3163-72.

VARGOVÁ L, SYKOVÁ E. Astrocytes and extracellular matrix in extrasynaptic volume transmission. (2014) Philos Trans R Soc Lond B Biol Sci. 369(1654):20130608.

AMEMORI T, JENDELOVA P, RUZICKA J, URDZIKOVA LM, SYKOVA E. (2015) Alzheimer’s Disease: Mechanism and Approach to Cell Therapy. Int J Mol Sci. 16:26417-51.

JENDELOVÁ P, KUBINOVÁ Š, SANDVIG I, ERCEG S, SANDVIG A, SYKOVÁ E. (2016) Current developments in cell- and biomaterial-based approaches for stroke repair. Expert Opin Biol Ther.  16:43-56.

HERYNEK V, TURNOVCOVÁ K, VEVERKA P, DĚDOURKOVÁ T, ŽVÁTORA P, JENDELOVÁ P, GÁLISOVÁ A, KOSINOVÁ L, JIRÁKOVÁ K, SYKOVÁ E. (2016) Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation. Int J Nanomedicine. 11:3801-11.