Eriko Takano

Associate Professor in Synthetic Microbiology
Department of Microbial Physiology
University of Groningen

Fields of interest: 

Synthetic biology of antibiotic production

Novel antibiotic discovery by post genomics

Gamma butyrolactone signalling system in Streptomyces coelicolor

Noncoding RNA in Streptomyces

Metabolomic analysis in Streptomyces

Metabolite modelling and bioinformatics


Recent publications:

Takano E, Bovenberg R, Breitling R:
A turning point for natural product discovery – ESF- EMBO research conference: synthetic biology of antibiotic production.
Mol Micro., (2012) 83:884-93.

Medema MH, van Raaphorst R, Takano E, Breitling R:
Computational tools for the synthetic design of biochemical pathways.
Nature Rev. Microbiol., (2012) 10:191-202.

Jankevics A, Merlo ME, de Vries M, Vonk RJ, Takano E, Breitling R:
Metabolomic analysis of a synthetic metabolic switch in Streptomyces coelicolor A3(2).
Proteomics, (2012) 11:4622-31.

Merlo ME, Jankevics A, Takano E, Breitling R:
Exploring the metabolic state of microorganisms using metabolomics.
Bioanalysis, 3, (2011):2443-2458.

Alam MT, Takano E, Breitling R:
Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor.
BMC Research Notes, 4, (2011): 325.

Jankevics A, Merlo ME, de Vries M, Vonk RJ, Takano E, Breitling R:
Separating the wheat from the chaff: a prioritisation pipeline for the analysis of metabolomics datasets.
Metabolomics, (2012) in press.

Alam MT, Medema MH, Takano E, Breitling R:
Comparative genome-scale metabolic modeling of actinomycetes: The topology of essential core metabolism.
FEBS Letters 585, (2011): 2389–2394.

Medema MH, Balin K, Cimermanic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R:
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.
Nucl Acids Res., 39, (2011): W339–W346.

Chatterjee A, Drews L, Mehra S, Takano E, Kaznessis YN, Hu WS:
Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis.
PLoS One, 6, (2011): e21974.

Medema MH, Alam MT, Breitling R, Takano E:
The future of industrial antibiotic production: from random mutagenesis to synthetic biology.
Bioengineered Bugs, 2, (2011): 300–305.

Medema MH, Breitling R, Takano E:
Synthetic Biology in Streptomyces bacteria.
Methods in Enzymol., 497, (2011): 485-502.