Christine van Broeckhoven

Director of Department of Molecular Genetics
VIB Department of Molecular Genetics
University of Antwerpen, Belgium
E-mail: christine.vanbroeckhoven@molgen.vib-ua.be
Page: http://www.vib.be/en/research/scientists/Pages/Christine-Van-Broeckhoven-Lab.aspx

Fields of interest:

Genetics, genomics and neuropathology of the neurodegenerative brain diseases; Alzheimer’s disease, frontal temporal lobar degeneration and Parkinson’s disease.

Recent publications:

Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ:
Association of LRRK2 exonic variants with susceptibility to Parkinson’s disease: a case-control study.
Lancet Neurol., 2011, 10:898-908

Nosková L, Stránecký V, Hartmannová H, Přistoupilová A, Barešová V, Ivánek R, Hůlková H, Jahnová H, van der Zee J, Staropoli JF, Sims KB, Tyynelä J, Van Broeckhoven C, Nijssen PC, Mole SE, Elleder M, Kmoch S.:
Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis.
Am J Hum Genet., 2011, 89:241-52

Crosiers D, Theuns J, Cras P, Van Broeckhoven C.:
Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypes.
J Chem Neuroanat.,2011, 42:131-41

Janssens J, Kleinberger G, Wils H, Van Broeckhoven C.:
The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochem Soc Trans., 2011, 39:954-9

Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Van Broeckhoven C, Chartier-Harlin MC, Destée A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C, Lesage S, Lynch T, Lichtner P, Lambert JC, Lang AE, Mellick GD, De Nigris F, Opala G, Quattrone A, Riva C, Rogaeva E, Ross OA, Satake W, Silburn PA, Theuns J, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Gasser T, Krüger R:
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson’s disease.
Neurobiol Aging., 2011, 32:2108.e1-5

Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC.:
Potent amyloidogenicity and pathogenicity of Aβ43.
Nat Neurosci., 2011, 14:1023-32

van der Zee J, Van Broeckhoven C.:
TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration.
J Mol Neurosci.,2011 May 26

Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B:
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β’-site increases Aβ generation.
EMBO Mol Med., 2011, 3:291-302

Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL 3rd, Brooks WS, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Heutink P, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Bigio E, Lladó A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IR, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VM, Trojanowski JQ, Van Deerlin VM.:
Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.
Arch Neurol.,2011, 68:488-97

van der Zee J, Van Langenhove T, Kleinberger G, Sleegers K, Engelborghs S, Vandenberghe R, Santens P, Van den Broeck M, Joris G, Brys J, Mattheijssens M, Peeters K, Cras P, De Deyn PP, Cruts M, Van Broeckhoven C.:
TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.
Brain, 2011, 134:808-15