Ronald W. Woodard

Frederick F. Blicke Collegiate Professor and Chair of Medicinal Chemistry; Director, Interdepartmental Program in Medicinal Chemistry; Professor of Chemistry, LSA
College of Pharmacy
University of Michigan

Fields of interest: 

Enzyme Mechanism of Carbohydrate Biosynthetic Pathways


Recent publications:

Zhou L, Wu J, Janakiraman V, Shumilin IA, Bauerle R, Kretsinger RH, Woodard RW.:
Structure and characterization of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Aeropyrum pernix.
Bioorg Chem. Vol. 40(1), (2012), pp. 79-86.

Schmidt H, Mesters JR, Wu J, Woodard RW, Hilgenfeld R, Mamat U.:
Evidence for a two-metal-ion mechanism in the cytidyltransferase KdsB, an enzyme involved in lipopolysaccharide biosynthesis.
PLoS One.Vol. 6(8), (2011), e23231.

Yi L, Velasquez MS, Holler TP, Woodard RW.:
A simple assay for 3-deoxy-d-manno-octulosonate cytidylyltransferase and its use as a pathway screen.
Anal Biochem.Vol. 416(2), (2011), pp. 152-8.

Mosberg JA, Yep A, Meredith TC, Smith S, Wang PF, Holler TP, Mobley HL, Woodard RW.:
A unique arabinose 5-phosphate isomerase found within a genomic island associated with the uropathogenicity of Escherichia coli CFT073.
J Bacteriol.Vol. 193(12), (2011), pp. 2981-8.

Yep A, Sorenson RJ, Wilson MR, Showalter HD, Larsen SD, Keller PR, Woodard RW.:
Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis.
Bioorg Med Chem Lett.Vol. 21(9), (2011), pp. 2679-82.

Biswas T, Yi L, Aggarwal P, Wu J, Rubin JR, Stuckey JA,  Woodard RW, Tsodikov OV.:
The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase.
J Biol Chem.Vol. 284(44), (2009), pp. 30594-603.

Mamat U, Schmidt H, Munoz E, Lindner B, Fukase K, Hanuszkiewicz A, Wu J, Meredith TC, Woodard RW, Hilgenfeld R, Mesters JR, Holst O.:
WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis.
J Biol Chem., Vol. 284(33), (2009), pp. 22248-62.

Chen S, Tong X, Woodard RW, Du G, Wu J, Chen J.:
Identification and characterization of bacterial cutinase.
J Biol Chem. Vol. 283(38), (2008), pp. 25854-62.

Mamat U, Meredith TC, Aggarwal P, Kühl A, Kirchhoff P, Lindner B, Hanuszkiewicz A, Sun J, Holst O, Woodard RW.:
Single amino acid substitutions in either YhjD or MsbA confer viability to 3-deoxy-d-manno-oct-2-ulosonic acid-depleted Escherichia coli.
Mol Microbiol.Vol. 67(3), (2008), pp. 633-48.

Meredith TC, Mamat U, Kaczynski Z, Lindner B, Holst O, Woodard RW.:
Modification of lipopolysaccharide with colanic acid (M-antigen) repeats in Escherichia coli.
J Biol Chem.Vol. 282(11), (2007), pp. 7790-8.