Xi Liu

Postdoc Fellow
Lab of Cellular Oncology
National Cancer Institute, National Institutes of Health
E-mail: xi.liu@nih.gov

Fields of interest

miRNA in lung cancer and cervical cancer, mouse models for lung cancer and cervical cancer, cancer stem cell


Recent publications

Liu X, Sempere LF, Ouyang H, Freemantle SJ, Dragnev KH, Memoli VA, Li H, DiRenzo J, Korc M, Bak M, Kauppinen S, and Dmitrovsky E
MiR-31 act as a oncogenic miRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.
J Clin Invest, 2010;120(4):1298–1309.

Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli VA, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, and Dmitrovsky E
Uncovering growth suppressive microRNAs in lung cancer.
Clin Cancer Res, 2009;15:1177-1183.

Du X, Qian X, Papageorge A, Schetter AJ, Vass WC, Liu X, Braverman R, Robles AI, Lowy DR.
Functional Interaction of Tumor Suppressor DLC1 and Caveolin-1 in Cancer Cells.
Cancer Res. 2012, 72(17):4405-16.

Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E.
Bexarotene Plus Erlotinib Suppress Lung Carcinogenesis Independent of KRAS Mutations in Two Clinical Trials and Transgenic Models.
Cancer Prev Res 2011;4(6):818-28

Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E.
Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARαand inhibits the growth of acute promyelocytic leukemia.
Cancer Res. 2010;70(23):9875-85

Galimberti G, Thompson S, Liu X, Green SR, Memoli VA, Compton D, and Dmitrovsky E
Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe and apoptosis.
Clin Cancer Res, 2010; 16:109-20.

Feng Q, Sekula D, Guo Y, Liu X, Black CC, Galimberti F, Shah SJ, Sempere LF, Memoli V, Andersen JB, Hassel BA, Dragnev K, Dmitrovsky E
UBE1L causes lung cancer growth suppression by targeting cyclin D1.
Mol Cancer Ther, 2008;7:3780-8.

Ma Y, Fiering S, Black C, Liu X, Yuan Z, Memoli VA, Robbins DJ, Bentley HA, Tsongalis GJ, Demidenko E, Freemantle SJ, Dmitrovsky E
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.
Proc Natl Acad Sci USA, 2007;104:4089-94.

Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.
Mol Cancer Ther, 2008;7:1251-7.